Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution

Introduction: Breast cancer is the leading cause of cancer-related deaths in women aged 20-59 years. Younger women usually have more aggressive tumors and more advanced disease with larger size and axillary lymph node involvement. There have been few studies assessing the characteristics of breast...

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Autores principales:	Juliana Cunha e Silva Ominelli de Souza, Andrew Sá Nunes, Jesse Lopes da Silva, Aline Coelho Gonçalves, Suzanne Crocamo Ventilari da Costa
Formato:	article
Lenguaje:	EN PT
Publicado:	Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) 2018
Materias:	Breast Neoplasms Young Adult Health Services Research Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/dfae6702424549d69b7c97cc1b730f44
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spelling	oai:doaj.org-article:dfae6702424549d69b7c97cc1b730f442021-11-29T20:07:07ZReal-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution10.32635/2176-9745.RBC.2018v64n1.1160034-71162176-9745https://doaj.org/article/dfae6702424549d69b7c97cc1b730f442018-03-01T00:00:00Zhttps://rbc.inca.gov.br/revista/index.php/revista/article/view/116https://doaj.org/toc/0034-7116https://doaj.org/toc/2176-9745 Introduction: Breast cancer is the leading cause of cancer-related deaths in women aged 20-59 years. Younger women usually have more aggressive tumors and more advanced disease with larger size and axillary lymph node involvement. There have been few studies assessing the characteristics of breast cancer in very young women. Objective: Evaluate the epidemiological and clinical profile of non-metastatic very young patients with breast cancer. Method: We performed a retrospective analysis to evaluate the epidemiological and clinical profile of non-metastatic breast cancer in patients ≤ 30 years of age treated between 1993 and 2011 at the Brazilian National Cancer Institute José Alencar Gomes da Silva. We evaluated relapse-free survival (RFS) and overall survival (OS). Results: Of the 196 patients evaluated, 181 (90%) had ductal carcinoma, 79 (40%) had high-grade tumors, and 102 (52%) had hormone receptor-positive tumors. 117 patients (60%) had stage III disease at diagnosis. The median age was 29 years (range, 17-30 years). Of 185 patients who underwent surgery, 156 (84.3%) underwent total mastectomy and 171 (92%) underwent axillary lymph node dissection. 119 patients received neoadjuvant chemotherapy, and 14 patients (9.3%) underwent neoadjuvant radiotherapy. After a median follow-up of 81.5 months, 109 patients (55%) had relapsed and 81 (41%) had died. The median RFS and OS were 49.5 months and 134 months, respectively. Lymph node involvement and neoadjuvant chemotherapy were associated with shorter RFS and OS. Conclusion: Breast cancer is uncommon in young patients, especially in those ≤ 30 years of age. We found a predominance of locally advanced disease and worse prognostic pathological characteristics. Despite the aggressive treatment, our patients had worse outcomes than those reported by other authors. Juliana Cunha e Silva Ominelli de SouzaAndrew Sá NunesJesse Lopes da SilvaAline Coelho GonçalvesSuzanne Crocamo Ventilari da CostaInstituto Nacional de Câncer José Alencar Gomes da Silva (INCA)articleBreast NeoplasmsYoung AdultHealth Services ResearchNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENPTRevista Brasileira de Cancerologia, Vol 64, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Breast Neoplasms Young Adult Health Services Research Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast Neoplasms Young Adult Health Services Research Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Juliana Cunha e Silva Ominelli de Souza Andrew Sá Nunes Jesse Lopes da Silva Aline Coelho Gonçalves Suzanne Crocamo Ventilari da Costa Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution
description	Introduction: Breast cancer is the leading cause of cancer-related deaths in women aged 20-59 years. Younger women usually have more aggressive tumors and more advanced disease with larger size and axillary lymph node involvement. There have been few studies assessing the characteristics of breast cancer in very young women. Objective: Evaluate the epidemiological and clinical profile of non-metastatic very young patients with breast cancer. Method: We performed a retrospective analysis to evaluate the epidemiological and clinical profile of non-metastatic breast cancer in patients ≤ 30 years of age treated between 1993 and 2011 at the Brazilian National Cancer Institute José Alencar Gomes da Silva. We evaluated relapse-free survival (RFS) and overall survival (OS). Results: Of the 196 patients evaluated, 181 (90%) had ductal carcinoma, 79 (40%) had high-grade tumors, and 102 (52%) had hormone receptor-positive tumors. 117 patients (60%) had stage III disease at diagnosis. The median age was 29 years (range, 17-30 years). Of 185 patients who underwent surgery, 156 (84.3%) underwent total mastectomy and 171 (92%) underwent axillary lymph node dissection. 119 patients received neoadjuvant chemotherapy, and 14 patients (9.3%) underwent neoadjuvant radiotherapy. After a median follow-up of 81.5 months, 109 patients (55%) had relapsed and 81 (41%) had died. The median RFS and OS were 49.5 months and 134 months, respectively. Lymph node involvement and neoadjuvant chemotherapy were associated with shorter RFS and OS. Conclusion: Breast cancer is uncommon in young patients, especially in those ≤ 30 years of age. We found a predominance of locally advanced disease and worse prognostic pathological characteristics. Despite the aggressive treatment, our patients had worse outcomes than those reported by other authors.
format	article
author	Juliana Cunha e Silva Ominelli de Souza Andrew Sá Nunes Jesse Lopes da Silva Aline Coelho Gonçalves Suzanne Crocamo Ventilari da Costa
author_facet	Juliana Cunha e Silva Ominelli de Souza Andrew Sá Nunes Jesse Lopes da Silva Aline Coelho Gonçalves Suzanne Crocamo Ventilari da Costa
author_sort	Juliana Cunha e Silva Ominelli de Souza
title	Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution
title_short	Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution
title_full	Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution
title_fullStr	Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution
title_full_unstemmed	Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution
title_sort	real-world data related to non-metastatic breast cancer in young women: experience of a single institution
publisher	Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
publishDate	2018
url	https://doaj.org/article/dfae6702424549d69b7c97cc1b730f44
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Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution

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