Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.

Acute Respiratory Infections (ARI) are some of the most common human diseases worldwide. However, they have a complex and diverse etiology, and the characteristics of the pathogens involved in respiratory infections in developing countries are not well understood. In this work, we analyzed the chara...

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Autores principales:	Wen Kuan Liu, Qian Liu, De Hui Chen, Huan Xi Liang, Xiao Kai Chen, Mei Xin Chen, Shu Yan Qiu, Zi Yeng Yang, Rong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfaf85999b1d48138cf1ba8ffeebeb6d
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spelling	oai:doaj.org-article:dfaf85999b1d48138cf1ba8ffeebeb6d2021-11-18T08:20:47ZEpidemiology of acute respiratory infections in children in Guangzhou: a three-year study.1932-620310.1371/journal.pone.0096674https://doaj.org/article/dfaf85999b1d48138cf1ba8ffeebeb6d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24797911/?tool=EBIhttps://doaj.org/toc/1932-6203Acute Respiratory Infections (ARI) are some of the most common human diseases worldwide. However, they have a complex and diverse etiology, and the characteristics of the pathogens involved in respiratory infections in developing countries are not well understood. In this work, we analyzed the characteristics of 17 common respiratory pathogens in children (≤14 years old) with ARI in Guangzhou, southern China over a 3-year period using real-time polymerase chain reaction. Pathogens were identified in 2361/4242 (55.7%) patients, and the positivity rate varied seasonally. Ten of the 17 pathogens investigated showed positivity rates of more than 5%. The most frequently detected pathogens were respiratory syncytial virus (768/2361, 32.5%), influenza A virus (428/2361, 18.1%), enterovirus (138/2361, 13.3%), Mycoplasma pneumoniae (267/2361, 11.3%) and adenovirus (213/2361, 9.0%). Co-pathogens were common and found in 503 of 2361 (21.3%) positive samples. When ranked according to frequency of occurrence, the pattern of co-pathogens was similar to that of the primary pathogens, with the exception of human bocavirus, human coronavirus and human metapneumovirus. Significant differences were found in age prevalence in 10 of the 17 pathogens (p≤0.009): four basic patterns were observed, A: detection rates increased with age, B: detection rates declined with age, C: the detection rate showed distinct peaks or D: numbers of patients were too low to detect a trend or showed no significant difference among age groups (p>0.05). These data will be useful for planning vaccine research and control strategies and for studies predicting pathogen prevalence.Wen Kuan LiuQian LiuDe Hui ChenHuan Xi LiangXiao Kai ChenMei Xin ChenShu Yan QiuZi Yeng YangRong ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96674 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wen Kuan Liu Qian Liu De Hui Chen Huan Xi Liang Xiao Kai Chen Mei Xin Chen Shu Yan Qiu Zi Yeng Yang Rong Zhou Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.
description	Acute Respiratory Infections (ARI) are some of the most common human diseases worldwide. However, they have a complex and diverse etiology, and the characteristics of the pathogens involved in respiratory infections in developing countries are not well understood. In this work, we analyzed the characteristics of 17 common respiratory pathogens in children (≤14 years old) with ARI in Guangzhou, southern China over a 3-year period using real-time polymerase chain reaction. Pathogens were identified in 2361/4242 (55.7%) patients, and the positivity rate varied seasonally. Ten of the 17 pathogens investigated showed positivity rates of more than 5%. The most frequently detected pathogens were respiratory syncytial virus (768/2361, 32.5%), influenza A virus (428/2361, 18.1%), enterovirus (138/2361, 13.3%), Mycoplasma pneumoniae (267/2361, 11.3%) and adenovirus (213/2361, 9.0%). Co-pathogens were common and found in 503 of 2361 (21.3%) positive samples. When ranked according to frequency of occurrence, the pattern of co-pathogens was similar to that of the primary pathogens, with the exception of human bocavirus, human coronavirus and human metapneumovirus. Significant differences were found in age prevalence in 10 of the 17 pathogens (p≤0.009): four basic patterns were observed, A: detection rates increased with age, B: detection rates declined with age, C: the detection rate showed distinct peaks or D: numbers of patients were too low to detect a trend or showed no significant difference among age groups (p>0.05). These data will be useful for planning vaccine research and control strategies and for studies predicting pathogen prevalence.
format	article
author	Wen Kuan Liu Qian Liu De Hui Chen Huan Xi Liang Xiao Kai Chen Mei Xin Chen Shu Yan Qiu Zi Yeng Yang Rong Zhou
author_facet	Wen Kuan Liu Qian Liu De Hui Chen Huan Xi Liang Xiao Kai Chen Mei Xin Chen Shu Yan Qiu Zi Yeng Yang Rong Zhou
author_sort	Wen Kuan Liu
title	Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.
title_short	Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.
title_full	Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.
title_fullStr	Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.
title_full_unstemmed	Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.
title_sort	epidemiology of acute respiratory infections in children in guangzhou: a three-year study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/dfaf85999b1d48138cf1ba8ffeebeb6d
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Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study.

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