Intrinsic network activity reflects the ongoing experience of chronic pain

Abstract Analyses of intrinsic network activity have been instrumental in revealing cortical processes that are altered in chronic pain patients. In a novel approach, we aimed to elucidate how intrinsic functional networks evolve in regard to the fluctuating intensity of the experience of chronic pa...

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Autores principales:	Pauline Jahn, Bettina Deak, Astrid Mayr, Anne Stankewitz, Daniel Keeser, Ludovica Griffanti, Viktor Witkovsky, Stephanie Irving, Enrico Schulz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfb1a624bcc34e37b947e79548b84116
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spelling	oai:doaj.org-article:dfb1a624bcc34e37b947e79548b841162021-11-14T12:18:10ZIntrinsic network activity reflects the ongoing experience of chronic pain10.1038/s41598-021-01340-02045-2322https://doaj.org/article/dfb1a624bcc34e37b947e79548b841162021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01340-0https://doaj.org/toc/2045-2322Abstract Analyses of intrinsic network activity have been instrumental in revealing cortical processes that are altered in chronic pain patients. In a novel approach, we aimed to elucidate how intrinsic functional networks evolve in regard to the fluctuating intensity of the experience of chronic pain. In a longitudinal study with 156 fMRI sessions, 20 chronic back pain patients and 20 chronic migraine patients were asked to continuously rate the intensity of their endogenous pain. We investigated the relationship between the fluctuation of intrinsic network activity with the time course of subjective pain ratings. For chronic back pain, we found increased cortical network activity for the salience network and a local pontine network, as well as decreased network activity in the anterior and posterior default mode network for higher pain intensities. Higher pain intensities in chronic migraine were accompanied with lower activity in a prefrontal cortical network. By taking the perspective of the individual, we focused on the variability of the subjective perception of pain, which include phases of relatively low pain and phases of relatively high pain. The present design of the assessment of ongoing endogenous pain can be a powerful and promising tool to assess the signature of a patient’s endogenous pain encoding.Pauline JahnBettina DeakAstrid MayrAnne StankewitzDaniel KeeserLudovica GriffantiViktor WitkovskyStephanie IrvingEnrico SchulzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pauline Jahn Bettina Deak Astrid Mayr Anne Stankewitz Daniel Keeser Ludovica Griffanti Viktor Witkovsky Stephanie Irving Enrico Schulz Intrinsic network activity reflects the ongoing experience of chronic pain
description	Abstract Analyses of intrinsic network activity have been instrumental in revealing cortical processes that are altered in chronic pain patients. In a novel approach, we aimed to elucidate how intrinsic functional networks evolve in regard to the fluctuating intensity of the experience of chronic pain. In a longitudinal study with 156 fMRI sessions, 20 chronic back pain patients and 20 chronic migraine patients were asked to continuously rate the intensity of their endogenous pain. We investigated the relationship between the fluctuation of intrinsic network activity with the time course of subjective pain ratings. For chronic back pain, we found increased cortical network activity for the salience network and a local pontine network, as well as decreased network activity in the anterior and posterior default mode network for higher pain intensities. Higher pain intensities in chronic migraine were accompanied with lower activity in a prefrontal cortical network. By taking the perspective of the individual, we focused on the variability of the subjective perception of pain, which include phases of relatively low pain and phases of relatively high pain. The present design of the assessment of ongoing endogenous pain can be a powerful and promising tool to assess the signature of a patient’s endogenous pain encoding.
format	article
author	Pauline Jahn Bettina Deak Astrid Mayr Anne Stankewitz Daniel Keeser Ludovica Griffanti Viktor Witkovsky Stephanie Irving Enrico Schulz
author_facet	Pauline Jahn Bettina Deak Astrid Mayr Anne Stankewitz Daniel Keeser Ludovica Griffanti Viktor Witkovsky Stephanie Irving Enrico Schulz
author_sort	Pauline Jahn
title	Intrinsic network activity reflects the ongoing experience of chronic pain
title_short	Intrinsic network activity reflects the ongoing experience of chronic pain
title_full	Intrinsic network activity reflects the ongoing experience of chronic pain
title_fullStr	Intrinsic network activity reflects the ongoing experience of chronic pain
title_full_unstemmed	Intrinsic network activity reflects the ongoing experience of chronic pain
title_sort	intrinsic network activity reflects the ongoing experience of chronic pain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dfb1a624bcc34e37b947e79548b84116
work_keys_str_mv	AT paulinejahn intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT bettinadeak intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT astridmayr intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT annestankewitz intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT danielkeeser intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT ludovicagriffanti intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT viktorwitkovsky intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT stephanieirving intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain AT enricoschulz intrinsicnetworkactivityreflectstheongoingexperienceofchronicpain
_version_	1718429319055802368

Intrinsic network activity reflects the ongoing experience of chronic pain

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