Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine

Abstract Previous studies have demonstrated that somatosensory stimuli influence dopamine transmission in the mesolimbic reward system and can reduce drug-induced motor behaviors, craving and dependence. Until now, the central links between somatosensory and brain reward systems are not known. Here,...

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Autores principales:	Suchan Chang, Yeonhee Ryu, Young Seob Gwak, Nam Jun Kim, Jin Mook Kim, Jun Yeon Lee, Seol Ah Kim, Bong Hyo Lee, Scott C. Steffensen, Eun Young Jang, Chae Ha Yang, Hee Young Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfb3da8c998d46a89558ae55ec8de7f6
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spelling	oai:doaj.org-article:dfb3da8c998d46a89558ae55ec8de7f62021-12-02T15:06:13ZSpinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine10.1038/s41598-017-05681-72045-2322https://doaj.org/article/dfb3da8c998d46a89558ae55ec8de7f62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05681-7https://doaj.org/toc/2045-2322Abstract Previous studies have demonstrated that somatosensory stimuli influence dopamine transmission in the mesolimbic reward system and can reduce drug-induced motor behaviors, craving and dependence. Until now, the central links between somatosensory and brain reward systems are not known. Here, we show that the dorsal column (DC) somatosensory pathway contains projections that convey an inhibitory input from the periphery to mesolimbic reward circuits. Stimulation of the ulnar nerve under HT7 acupoint suppressed psychomotor response to cocaine, which was abolished by disruption of the DC pathway, but not the spinothalamic tract (STT). Low-threshold or wide-dynamic range neurons in the cuneate nucleus (CN) were excited by peripheral stimulation. Lesions of dorsal column or lateral habenula (LHb) prevented the inhibitory effects of peripheral stimulation on cocaine-induced neuronal activation in the nucleus accumbens (NAc). LHb neurons projecting to the ventral tegmental area (VTA)/rostromedial tegmental nucleus (RMTg) regions were activated by peripheral stimulation and LHb lesions reversed the inhibitory effects on cocaine locomotion produced by peripheral stimulation. These findings suggest that there exists a pathway in spinal cord that ascends from periphery to mesolimbic reward circuits (spino-mesolimbic pathway) and the activation of somatosensory input transmitted via the DC pathway can inhibit the psychomotor response to cocaine.Suchan ChangYeonhee RyuYoung Seob GwakNam Jun KimJin Mook KimJun Yeon LeeSeol Ah KimBong Hyo LeeScott C. SteffensenEun Young JangChae Ha YangHee Young KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suchan Chang Yeonhee Ryu Young Seob Gwak Nam Jun Kim Jin Mook Kim Jun Yeon Lee Seol Ah Kim Bong Hyo Lee Scott C. Steffensen Eun Young Jang Chae Ha Yang Hee Young Kim Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
description	Abstract Previous studies have demonstrated that somatosensory stimuli influence dopamine transmission in the mesolimbic reward system and can reduce drug-induced motor behaviors, craving and dependence. Until now, the central links between somatosensory and brain reward systems are not known. Here, we show that the dorsal column (DC) somatosensory pathway contains projections that convey an inhibitory input from the periphery to mesolimbic reward circuits. Stimulation of the ulnar nerve under HT7 acupoint suppressed psychomotor response to cocaine, which was abolished by disruption of the DC pathway, but not the spinothalamic tract (STT). Low-threshold or wide-dynamic range neurons in the cuneate nucleus (CN) were excited by peripheral stimulation. Lesions of dorsal column or lateral habenula (LHb) prevented the inhibitory effects of peripheral stimulation on cocaine-induced neuronal activation in the nucleus accumbens (NAc). LHb neurons projecting to the ventral tegmental area (VTA)/rostromedial tegmental nucleus (RMTg) regions were activated by peripheral stimulation and LHb lesions reversed the inhibitory effects on cocaine locomotion produced by peripheral stimulation. These findings suggest that there exists a pathway in spinal cord that ascends from periphery to mesolimbic reward circuits (spino-mesolimbic pathway) and the activation of somatosensory input transmitted via the DC pathway can inhibit the psychomotor response to cocaine.
format	article
author	Suchan Chang Yeonhee Ryu Young Seob Gwak Nam Jun Kim Jin Mook Kim Jun Yeon Lee Seol Ah Kim Bong Hyo Lee Scott C. Steffensen Eun Young Jang Chae Ha Yang Hee Young Kim
author_facet	Suchan Chang Yeonhee Ryu Young Seob Gwak Nam Jun Kim Jin Mook Kim Jun Yeon Lee Seol Ah Kim Bong Hyo Lee Scott C. Steffensen Eun Young Jang Chae Ha Yang Hee Young Kim
author_sort	Suchan Chang
title	Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
title_short	Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
title_full	Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
title_fullStr	Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
title_full_unstemmed	Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
title_sort	spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dfb3da8c998d46a89558ae55ec8de7f6
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Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine

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