Layer-specific cholinergic control of human and mouse cortical synaptic plasticity

Nicotinic acetylcholine receptors (nAChRs) are differentially expressed across cortical layers, yet it is unclear whether they show layer-specific effects on synaptic plasticity in the prefrontal cortex. Here, the authors compare nAChRs across L6 and L2/3 in human and mouse cortex and find they medi...

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Autores principales:	Matthijs B. Verhoog, Joshua Obermayer, Christian A. Kortleven, René Wilbers, Jordi Wester, Johannes C. Baayen, Christiaan P. J. De Kock, Rhiannon M. Meredith, Huibert D. Mansvelder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfb3fee0fe6243589a8dcbee3f84b457
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spelling	oai:doaj.org-article:dfb3fee0fe6243589a8dcbee3f84b4572021-12-02T17:31:19ZLayer-specific cholinergic control of human and mouse cortical synaptic plasticity10.1038/ncomms128262041-1723https://doaj.org/article/dfb3fee0fe6243589a8dcbee3f84b4572016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12826https://doaj.org/toc/2041-1723Nicotinic acetylcholine receptors (nAChRs) are differentially expressed across cortical layers, yet it is unclear whether they show layer-specific effects on synaptic plasticity in the prefrontal cortex. Here, the authors compare nAChRs across L6 and L2/3 in human and mouse cortex and find they mediate opposite effects on synaptic plasticity.Matthijs B. VerhoogJoshua ObermayerChristian A. KortlevenRené WilbersJordi WesterJohannes C. BaayenChristiaan P. J. De KockRhiannon M. MeredithHuibert D. MansvelderNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthijs B. Verhoog Joshua Obermayer Christian A. Kortleven René Wilbers Jordi Wester Johannes C. Baayen Christiaan P. J. De Kock Rhiannon M. Meredith Huibert D. Mansvelder Layer-specific cholinergic control of human and mouse cortical synaptic plasticity
description	Nicotinic acetylcholine receptors (nAChRs) are differentially expressed across cortical layers, yet it is unclear whether they show layer-specific effects on synaptic plasticity in the prefrontal cortex. Here, the authors compare nAChRs across L6 and L2/3 in human and mouse cortex and find they mediate opposite effects on synaptic plasticity.
format	article
author	Matthijs B. Verhoog Joshua Obermayer Christian A. Kortleven René Wilbers Jordi Wester Johannes C. Baayen Christiaan P. J. De Kock Rhiannon M. Meredith Huibert D. Mansvelder
author_facet	Matthijs B. Verhoog Joshua Obermayer Christian A. Kortleven René Wilbers Jordi Wester Johannes C. Baayen Christiaan P. J. De Kock Rhiannon M. Meredith Huibert D. Mansvelder
author_sort	Matthijs B. Verhoog
title	Layer-specific cholinergic control of human and mouse cortical synaptic plasticity
title_short	Layer-specific cholinergic control of human and mouse cortical synaptic plasticity
title_full	Layer-specific cholinergic control of human and mouse cortical synaptic plasticity
title_fullStr	Layer-specific cholinergic control of human and mouse cortical synaptic plasticity
title_full_unstemmed	Layer-specific cholinergic control of human and mouse cortical synaptic plasticity
title_sort	layer-specific cholinergic control of human and mouse cortical synaptic plasticity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dfb3fee0fe6243589a8dcbee3f84b457
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Layer-specific cholinergic control of human and mouse cortical synaptic plasticity

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