The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes

A variety of studies have demonstrated the role of lipocalin 2 (LCN2) in both diabetes and neurological disorders. Nevertheless, the relationship between LCN2 and diabetic peripheral neuropathy (DPN) needs to be elucidated in humans. Therefore, this study aimed to investigate the association of LCN2...

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Autores principales:	Xi Zhang, Xiurong Shen, Wan Zhou, Mengyun Xu, Yan Xing, Jianping Weng, Shandong Ye, Suowen Xu, Zhi Zhang, Wei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	diabetic peripheral neuropathy diabetic complication lipocalin 2 type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doi.org/10.1530/EC-21-0290 https://doaj.org/article/dfb71237b6034673b9425ca3c43a26fa
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spelling	oai:doaj.org-article:dfb71237b6034673b9425ca3c43a26fa2021-11-10T08:22:45ZThe association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabeteshttps://doi.org/10.1530/EC-21-02902049-3614https://doaj.org/article/dfb71237b6034673b9425ca3c43a26fa2021-11-01T00:00:00Zhttps://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0290.xmlhttps://doaj.org/toc/2049-3614A variety of studies have demonstrated the role of lipocalin 2 (LCN2) in both diabetes and neurological disorders. Nevertheless, the relationship between LCN2 and diabetic peripheral neuropathy (DPN) needs to be elucidated in humans. Therefore, this study aimed to investigate the association of LCN2 with DPN in type 2 diabetes (T2D). A total of 207 participants with T2D and 40 participants with normal glucose tolerance (NGT) were included in this study. All participants were classified in to DPN group and non-DPN (NDPN) group based on the Toronto Clinical Neuropathy Scoring (TCNS). Demographic and biochemical parameters were measured. Serum LCN2 levels wer e determined using an ELISA technique. Serum LCN2 levels in NGT group were lower t han those in either DPN group (P = 0.000) or NDPN group (P = 0.043), while serum LCN2 levels in DPN group were higher than NDPN group (P = 0.001). Moreover, serum LCN2 levels positively correlated to TCNS scores, which reflects neuropathy severity ( r = 0.438, P = 0.000). Multivariate stepwise regression analysis showed that BMI, triglycerides, an d diastolic pressure were independently associated with serum LCN2 in DPN. Additionally, logistic regression analysis demonstrated that LCN2 (odds ratio (OR) = 1.009) and diabetes duration (OR = 1.058) were independently associated with the occurrence of DP N in T2D. Our report reveals the association of serum LCN2 with DPN in T2D. LCN2 mig ht be used to evaluate DPN severity and serve a role in the pathogenesis of DPN.Xi ZhangXiurong ShenWan ZhouMengyun XuYan XingJianping WengShandong YeSuowen XuZhi ZhangWei WangBioscientificaarticlediabetic peripheral neuropathydiabetic complicationlipocalin 2type 2 diabetesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Connections, Vol 10, Iss 11, Pp 1403-1409 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic peripheral neuropathy diabetic complication lipocalin 2 type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	diabetic peripheral neuropathy diabetic complication lipocalin 2 type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Xi Zhang Xiurong Shen Wan Zhou Mengyun Xu Yan Xing Jianping Weng Shandong Ye Suowen Xu Zhi Zhang Wei Wang The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
description	A variety of studies have demonstrated the role of lipocalin 2 (LCN2) in both diabetes and neurological disorders. Nevertheless, the relationship between LCN2 and diabetic peripheral neuropathy (DPN) needs to be elucidated in humans. Therefore, this study aimed to investigate the association of LCN2 with DPN in type 2 diabetes (T2D). A total of 207 participants with T2D and 40 participants with normal glucose tolerance (NGT) were included in this study. All participants were classified in to DPN group and non-DPN (NDPN) group based on the Toronto Clinical Neuropathy Scoring (TCNS). Demographic and biochemical parameters were measured. Serum LCN2 levels wer e determined using an ELISA technique. Serum LCN2 levels in NGT group were lower t han those in either DPN group (P = 0.000) or NDPN group (P = 0.043), while serum LCN2 levels in DPN group were higher than NDPN group (P = 0.001). Moreover, serum LCN2 levels positively correlated to TCNS scores, which reflects neuropathy severity ( r = 0.438, P = 0.000). Multivariate stepwise regression analysis showed that BMI, triglycerides, an d diastolic pressure were independently associated with serum LCN2 in DPN. Additionally, logistic regression analysis demonstrated that LCN2 (odds ratio (OR) = 1.009) and diabetes duration (OR = 1.058) were independently associated with the occurrence of DP N in T2D. Our report reveals the association of serum LCN2 with DPN in T2D. LCN2 mig ht be used to evaluate DPN severity and serve a role in the pathogenesis of DPN.
format	article
author	Xi Zhang Xiurong Shen Wan Zhou Mengyun Xu Yan Xing Jianping Weng Shandong Ye Suowen Xu Zhi Zhang Wei Wang
author_facet	Xi Zhang Xiurong Shen Wan Zhou Mengyun Xu Yan Xing Jianping Weng Shandong Ye Suowen Xu Zhi Zhang Wei Wang
author_sort	Xi Zhang
title	The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
title_short	The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
title_full	The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
title_fullStr	The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
title_full_unstemmed	The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
title_sort	association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/EC-21-0290 https://doaj.org/article/dfb71237b6034673b9425ca3c43a26fa
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The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes

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