Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice

Abstract Neurodevelopmental disorders are conditions caused by the abnormal development of the central nervous system. Autism spectrum disorder (ASD) is currently the most common form of such disorders, affecting 1% of the population worldwide. Despite its prevalence, the mechanisms underlying ASD a...

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Autores principales:	Kazi Farhana Afroz, Noah Reyes, Kobe Young, Kajal Parikh, Varsha Misra, Karina Alviña
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfbb9b2b1a234659a5906a11155c2c14
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spelling	oai:doaj.org-article:dfbb9b2b1a234659a5906a11155c2c142021-12-02T14:26:25ZAltered gut microbiome and autism like behavior are associated with parental high salt diet in male mice10.1038/s41598-021-87678-x2045-2322https://doaj.org/article/dfbb9b2b1a234659a5906a11155c2c142021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87678-xhttps://doaj.org/toc/2045-2322Abstract Neurodevelopmental disorders are conditions caused by the abnormal development of the central nervous system. Autism spectrum disorder (ASD) is currently the most common form of such disorders, affecting 1% of the population worldwide. Despite its prevalence, the mechanisms underlying ASD are not fully known. Recent studies have suggested that the maternal gut microbiome can have profound effects on neurodevelopment. Considering that the gut microbial composition is modulated by diet, we tested the hypothesis that ASD-like behavior could be linked to maternal diet and its associated gut dysbiosis. Therefore, we used a mouse model of parental high salt diet (HSD), and specifically evaluated social and exploratory behaviors in their control-fed offspring. Using 16S genome sequencing of fecal samples, we first show that (1) as expected, HSD changed the maternal gut microbiome, and (2) this altered gut microbiome was shared with the offspring. More importantly, behavioral analysis of the offspring showed hyperactivity, increased repetitive behaviors, and impaired sociability in adult male mice from HSD-fed parents. Taken together, our data suggests that parental HSD consumption is strongly associated with offspring ASD-like behavioral abnormalities via changes in gut microbiome.Kazi Farhana AfrozNoah ReyesKobe YoungKajal ParikhVarsha MisraKarina AlviñaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazi Farhana Afroz Noah Reyes Kobe Young Kajal Parikh Varsha Misra Karina Alviña Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
description	Abstract Neurodevelopmental disorders are conditions caused by the abnormal development of the central nervous system. Autism spectrum disorder (ASD) is currently the most common form of such disorders, affecting 1% of the population worldwide. Despite its prevalence, the mechanisms underlying ASD are not fully known. Recent studies have suggested that the maternal gut microbiome can have profound effects on neurodevelopment. Considering that the gut microbial composition is modulated by diet, we tested the hypothesis that ASD-like behavior could be linked to maternal diet and its associated gut dysbiosis. Therefore, we used a mouse model of parental high salt diet (HSD), and specifically evaluated social and exploratory behaviors in their control-fed offspring. Using 16S genome sequencing of fecal samples, we first show that (1) as expected, HSD changed the maternal gut microbiome, and (2) this altered gut microbiome was shared with the offspring. More importantly, behavioral analysis of the offspring showed hyperactivity, increased repetitive behaviors, and impaired sociability in adult male mice from HSD-fed parents. Taken together, our data suggests that parental HSD consumption is strongly associated with offspring ASD-like behavioral abnormalities via changes in gut microbiome.
format	article
author	Kazi Farhana Afroz Noah Reyes Kobe Young Kajal Parikh Varsha Misra Karina Alviña
author_facet	Kazi Farhana Afroz Noah Reyes Kobe Young Kajal Parikh Varsha Misra Karina Alviña
author_sort	Kazi Farhana Afroz
title	Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
title_short	Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
title_full	Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
title_fullStr	Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
title_full_unstemmed	Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
title_sort	altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dfbb9b2b1a234659a5906a11155c2c14
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Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice

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