Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants

Abstract Altogether, 20–30% of women receive intrapartum antibiotic prophylaxis (IAP) to prevent sepsis in infants and 2–5% of newborn infants receive antibiotics due to suspected sepsis. Caesarean section has a long-term impact on the intestinal microbiome but the effects of perinatal antibiotics o...

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Autores principales:	Terhi Tapiainen, Pirjo Koivusaari, Lauren Brinkac, Hernan A. Lorenzi, Jarmo Salo, Marjo Renko, Hannele Pruikkonen, Tytti Pokka, Weizhong Li, Karen Nelson, Anna Maria Pirttilä, Mysore V. Tejesvi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfbdaa78828f49a8add15e6ed936cf89
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spelling	oai:doaj.org-article:dfbdaa78828f49a8add15e6ed936cf892021-12-02T16:08:43ZImpact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants10.1038/s41598-019-46964-52045-2322https://doaj.org/article/dfbdaa78828f49a8add15e6ed936cf892019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46964-5https://doaj.org/toc/2045-2322Abstract Altogether, 20–30% of women receive intrapartum antibiotic prophylaxis (IAP) to prevent sepsis in infants and 2–5% of newborn infants receive antibiotics due to suspected sepsis. Caesarean section has a long-term impact on the intestinal microbiome but the effects of perinatal antibiotics on gut microbiome in vaginally delivered infants are not well known. We compared the impact of IAP, postnatal antibiotics, or their combination on the gut microbiome and emergence of antimicrobial resistance in a controlled study of 149 newborn infants recruited within 24 hours after birth. We collected 659 fecal samples, including 426 daily samples from infants before discharge from the hospital and 111 follow-up samples at six months. Penicillin was mostly used for IAP and the combination of penicillin and aminoglycoside for postnatal treatment. Postnatal antibiotic groups received Lactobacillus reuteri probiotic. Newborn gut colonization differed in both IAP and postnatal antibiotics groups as compared to that in control group. The effect size of IAP was comparable to that caused by postnatal antibiotics. The observed differences were still present at six months and not prevented by lactobacilli consumption. Given the present clinical results, the impact of perinatal antibiotics on the subsequent health of newborn infants should be further evaluated.Terhi TapiainenPirjo KoivusaariLauren BrinkacHernan A. LorenziJarmo SaloMarjo RenkoHannele PruikkonenTytti PokkaWeizhong LiKaren NelsonAnna Maria PirttiläMysore V. TejesviNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Terhi Tapiainen Pirjo Koivusaari Lauren Brinkac Hernan A. Lorenzi Jarmo Salo Marjo Renko Hannele Pruikkonen Tytti Pokka Weizhong Li Karen Nelson Anna Maria Pirttilä Mysore V. Tejesvi Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants
description	Abstract Altogether, 20–30% of women receive intrapartum antibiotic prophylaxis (IAP) to prevent sepsis in infants and 2–5% of newborn infants receive antibiotics due to suspected sepsis. Caesarean section has a long-term impact on the intestinal microbiome but the effects of perinatal antibiotics on gut microbiome in vaginally delivered infants are not well known. We compared the impact of IAP, postnatal antibiotics, or their combination on the gut microbiome and emergence of antimicrobial resistance in a controlled study of 149 newborn infants recruited within 24 hours after birth. We collected 659 fecal samples, including 426 daily samples from infants before discharge from the hospital and 111 follow-up samples at six months. Penicillin was mostly used for IAP and the combination of penicillin and aminoglycoside for postnatal treatment. Postnatal antibiotic groups received Lactobacillus reuteri probiotic. Newborn gut colonization differed in both IAP and postnatal antibiotics groups as compared to that in control group. The effect size of IAP was comparable to that caused by postnatal antibiotics. The observed differences were still present at six months and not prevented by lactobacilli consumption. Given the present clinical results, the impact of perinatal antibiotics on the subsequent health of newborn infants should be further evaluated.
format	article
author	Terhi Tapiainen Pirjo Koivusaari Lauren Brinkac Hernan A. Lorenzi Jarmo Salo Marjo Renko Hannele Pruikkonen Tytti Pokka Weizhong Li Karen Nelson Anna Maria Pirttilä Mysore V. Tejesvi
author_facet	Terhi Tapiainen Pirjo Koivusaari Lauren Brinkac Hernan A. Lorenzi Jarmo Salo Marjo Renko Hannele Pruikkonen Tytti Pokka Weizhong Li Karen Nelson Anna Maria Pirttilä Mysore V. Tejesvi
author_sort	Terhi Tapiainen
title	Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants
title_short	Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants
title_full	Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants
title_fullStr	Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants
title_full_unstemmed	Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants
title_sort	impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dfbdaa78828f49a8add15e6ed936cf89
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Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants

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