Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study

Abstract Background With the increasing number of breast cancer (BC) diagnosed as a second primary malignancy after a first primary non-breast cancer (BCa-2), it is unclear about the familial risk of BC among women with a first-degree relative (FDR, parents or siblings) affected by a BCa-2. Methods...

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Autores principales:	Guoqiao Zheng, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Breast carcinoma Cancer incidence Familial clustering Multiple primary cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/dfbe0b7d8e5049ad8f9d5c71825c5c5c
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spelling	oai:doaj.org-article:dfbe0b7d8e5049ad8f9d5c71825c5c5c2021-11-14T12:30:29ZFamily history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study10.1186/s12885-021-08925-y1471-2407https://doaj.org/article/dfbe0b7d8e5049ad8f9d5c71825c5c5c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08925-yhttps://doaj.org/toc/1471-2407Abstract Background With the increasing number of breast cancer (BC) diagnosed as a second primary malignancy after a first primary non-breast cancer (BCa-2), it is unclear about the familial risk of BC among women with a first-degree relative (FDR, parents or siblings) affected by a BCa-2. Methods In this Swedish nationwide cohort study, 5315 women with a FDR affected by BCa-2 and 115,048 women with a FDR affected by BC as the first primary cancer (BCa-1) were followed for the first primary invasive BC diagnosis. Relative risk (RR) of BC was estimated through Poisson regression by using 2,743,777 women without a family history of cancer as reference. The risk was stratified by the diagnostic age of BC in FDR, proband type, the time interval between the first primary cancer and BCa-2 in FDR as well as the site of first primary cancer diagnosed in FDR before BCa-2. We also calculated the cumulative incidence of BC from birth to a specific age for the three groups. Results The cumulative incidence from birth to age 70 was 10% among women with a family history of BCa-2. The RR of BC with a family history of BCa-2 (RR, 1.68, 95%CI, 1.49 to 1.88) was comparable to that with BCa-1 (1.68, 1.63 to 1.73). The risk was largely consistent irrespective of proband type. The age of onset of BCa-2 in FDR (RR early-onset, 1.72 vs. RR late-onset 1.67) had less influence on the risk compared to BCa-1 in FDR (1.89 vs. 1.63). In the analysis stratified by the time between the first primary cancer and BCa-2 in relatives, the risks were largely similar. For the site of first primary cancer diagnosed in FDR before BCa-2, the increased BC risk was found in women whose FDRs were diagnosed with first primary gastric, colorectal, endometrial, ovarian, nervous system and endocrine gland cancers, and non-Hodgkin lymphoma. Conclusions Women with a family history of BCa-2 have a similar overall BC risk as those with a family history of BCa-1. The risk varied according to the site of first primary cancer diagnosed in FDR before BCa-2.Guoqiao ZhengJan SundquistKristina SundquistJianguang JiBMCarticleBreast carcinomaCancer incidenceFamilial clusteringMultiple primary cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast carcinoma Cancer incidence Familial clustering Multiple primary cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast carcinoma Cancer incidence Familial clustering Multiple primary cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Guoqiao Zheng Jan Sundquist Kristina Sundquist Jianguang Ji Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study
description	Abstract Background With the increasing number of breast cancer (BC) diagnosed as a second primary malignancy after a first primary non-breast cancer (BCa-2), it is unclear about the familial risk of BC among women with a first-degree relative (FDR, parents or siblings) affected by a BCa-2. Methods In this Swedish nationwide cohort study, 5315 women with a FDR affected by BCa-2 and 115,048 women with a FDR affected by BC as the first primary cancer (BCa-1) were followed for the first primary invasive BC diagnosis. Relative risk (RR) of BC was estimated through Poisson regression by using 2,743,777 women without a family history of cancer as reference. The risk was stratified by the diagnostic age of BC in FDR, proband type, the time interval between the first primary cancer and BCa-2 in FDR as well as the site of first primary cancer diagnosed in FDR before BCa-2. We also calculated the cumulative incidence of BC from birth to a specific age for the three groups. Results The cumulative incidence from birth to age 70 was 10% among women with a family history of BCa-2. The RR of BC with a family history of BCa-2 (RR, 1.68, 95%CI, 1.49 to 1.88) was comparable to that with BCa-1 (1.68, 1.63 to 1.73). The risk was largely consistent irrespective of proband type. The age of onset of BCa-2 in FDR (RR early-onset, 1.72 vs. RR late-onset 1.67) had less influence on the risk compared to BCa-1 in FDR (1.89 vs. 1.63). In the analysis stratified by the time between the first primary cancer and BCa-2 in relatives, the risks were largely similar. For the site of first primary cancer diagnosed in FDR before BCa-2, the increased BC risk was found in women whose FDRs were diagnosed with first primary gastric, colorectal, endometrial, ovarian, nervous system and endocrine gland cancers, and non-Hodgkin lymphoma. Conclusions Women with a family history of BCa-2 have a similar overall BC risk as those with a family history of BCa-1. The risk varied according to the site of first primary cancer diagnosed in FDR before BCa-2.
format	article
author	Guoqiao Zheng Jan Sundquist Kristina Sundquist Jianguang Ji
author_facet	Guoqiao Zheng Jan Sundquist Kristina Sundquist Jianguang Ji
author_sort	Guoqiao Zheng
title	Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study
title_short	Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study
title_full	Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study
title_fullStr	Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study
title_full_unstemmed	Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study
title_sort	family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/dfbe0b7d8e5049ad8f9d5c71825c5c5c
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_version_	1718429198730657792

Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study

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