Mitochondria as a Cellular Hub in Infection and Inflammation

Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell’s needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. M...

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Autores principales:	Pauline Andrieux, Christophe Chevillard, Edecio Cunha-Neto, João Paulo Silva Nunes
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitochondria inflammation infection mitochondria dysfunction mitochondrial bioenergetics infection disease Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/dfc0fabf707f44c282e9d30114853b89
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spelling	oai:doaj.org-article:dfc0fabf707f44c282e9d30114853b892021-11-11T16:49:07ZMitochondria as a Cellular Hub in Infection and Inflammation10.3390/ijms2221113381422-00671661-6596https://doaj.org/article/dfc0fabf707f44c282e9d30114853b892021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11338https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell’s needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. Mitochondria are a major site for production of Reactive Oxygen Species (ROS; or free radicals), which are essential to fight infection. However, excessive and uncontrolled production can become deleterious to the cell, leading to mitochondrial and tissue damage. Pathogens exploit the role of mitochondria during infection by affecting the oxidative phosphorylation mechanism (OXPHOS), mitochondrial network and disrupting the communication between the nucleus and the mitochondria. The role of mitochondria in these biological processes makes these organelle good targets for the development of therapeutic strategies. In this review, we presented a summary of the endosymbiotic origin of mitochondria and their involvement in the pathogen response, as well as the potential promising mitochondrial targets for the fight against infectious diseases and chronic inflammatory diseases.Pauline AndrieuxChristophe ChevillardEdecio Cunha-NetoJoão Paulo Silva NunesMDPI AGarticlemitochondriainflammationinfectionmitochondria dysfunctionmitochondrial bioenergeticsinfection diseaseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11338, p 11338 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria inflammation infection mitochondria dysfunction mitochondrial bioenergetics infection disease Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mitochondria inflammation infection mitochondria dysfunction mitochondrial bioenergetics infection disease Biology (General) QH301-705.5 Chemistry QD1-999 Pauline Andrieux Christophe Chevillard Edecio Cunha-Neto João Paulo Silva Nunes Mitochondria as a Cellular Hub in Infection and Inflammation
description	Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell’s needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. Mitochondria are a major site for production of Reactive Oxygen Species (ROS; or free radicals), which are essential to fight infection. However, excessive and uncontrolled production can become deleterious to the cell, leading to mitochondrial and tissue damage. Pathogens exploit the role of mitochondria during infection by affecting the oxidative phosphorylation mechanism (OXPHOS), mitochondrial network and disrupting the communication between the nucleus and the mitochondria. The role of mitochondria in these biological processes makes these organelle good targets for the development of therapeutic strategies. In this review, we presented a summary of the endosymbiotic origin of mitochondria and their involvement in the pathogen response, as well as the potential promising mitochondrial targets for the fight against infectious diseases and chronic inflammatory diseases.
format	article
author	Pauline Andrieux Christophe Chevillard Edecio Cunha-Neto João Paulo Silva Nunes
author_facet	Pauline Andrieux Christophe Chevillard Edecio Cunha-Neto João Paulo Silva Nunes
author_sort	Pauline Andrieux
title	Mitochondria as a Cellular Hub in Infection and Inflammation
title_short	Mitochondria as a Cellular Hub in Infection and Inflammation
title_full	Mitochondria as a Cellular Hub in Infection and Inflammation
title_fullStr	Mitochondria as a Cellular Hub in Infection and Inflammation
title_full_unstemmed	Mitochondria as a Cellular Hub in Infection and Inflammation
title_sort	mitochondria as a cellular hub in infection and inflammation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dfc0fabf707f44c282e9d30114853b89
work_keys_str_mv	AT paulineandrieux mitochondriaasacellularhubininfectionandinflammation AT christophechevillard mitochondriaasacellularhubininfectionandinflammation AT edeciocunhaneto mitochondriaasacellularhubininfectionandinflammation AT joaopaulosilvanunes mitochondriaasacellularhubininfectionandinflammation
_version_	1718432270653587456

Mitochondria as a Cellular Hub in Infection and Inflammation

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