Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality

Abstract Background COVID-19 pandemic is sweeping across the world. Previous studies have shown that gut microbiota is associated with COVID-19, and operational taxonomic unit (OTU) composed of Blautia genus, Lactobacillus genus, and Ruminococcus genus of Firmicutes is correlated with the severity o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Changjing Cai, Xiangyang Zhang, Yihan Liu, Edward Shen, Ziyang Feng, Cao Guo, Ying Han, Yanhong Ouyang, Hong Shen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Gut microbiota Colorectal cancer COVID-19 Mortality Prognosis Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/dfc3f10be6634ae39f2ad799499b35cf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dfc3f10be6634ae39f2ad799499b35cf
record_format	dspace
spelling	oai:doaj.org-article:dfc3f10be6634ae39f2ad799499b35cf2021-12-05T12:10:31ZGut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality10.1186/s13099-021-00466-w1757-4749https://doaj.org/article/dfc3f10be6634ae39f2ad799499b35cf2021-12-01T00:00:00Zhttps://doi.org/10.1186/s13099-021-00466-whttps://doaj.org/toc/1757-4749Abstract Background COVID-19 pandemic is sweeping across the world. Previous studies have shown that gut microbiota is associated with COVID-19, and operational taxonomic unit (OTU) composed of Blautia genus, Lactobacillus genus, and Ruminococcus genus of Firmicutes is correlated with the severity of COVID-19. Gut microbiota imbalance in colorectal cancer patients may lead to the variation of OTU. Results Based on the GMrepo database, the gut microbiota of 1374 patients with colorectal neoplasms and 27,329 healthy people was analyzed to investigate the differences in the abundance of microbes between colorectal neoplasms patients and healthy people. Furthermore, We collected feces samples from 12 patients with colorectal cancer and 8 healthy people in Xiangya hospital for metabolomic analysis to investigate the potential mechanisms. Our study showed that the abundance of Blautia and Ruminococcus was significantly increased in colorectal neoplasms, which may increase the severity of COVID-19. The gender and age of patients may affect the severity of COVID-19 by shaping the gut microbiota, but the BMI of patients does not. Conclusions Our work draws an initial point that gut microbiota imbalance is a risk factor of COVID-19 mortality and gut microbiota may provide a new therapeutic avenue for colorectal cancer patients.Changjing CaiXiangyang ZhangYihan LiuEdward ShenZiyang FengCao GuoYing HanYanhong OuyangHong ShenBMCarticleGut microbiotaColorectal cancerCOVID-19MortalityPrognosisDiseases of the digestive system. GastroenterologyRC799-869ENGut Pathogens, Vol 13, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gut microbiota Colorectal cancer COVID-19 Mortality Prognosis Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Gut microbiota Colorectal cancer COVID-19 Mortality Prognosis Diseases of the digestive system. Gastroenterology RC799-869 Changjing Cai Xiangyang Zhang Yihan Liu Edward Shen Ziyang Feng Cao Guo Ying Han Yanhong Ouyang Hong Shen Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality
description	Abstract Background COVID-19 pandemic is sweeping across the world. Previous studies have shown that gut microbiota is associated with COVID-19, and operational taxonomic unit (OTU) composed of Blautia genus, Lactobacillus genus, and Ruminococcus genus of Firmicutes is correlated with the severity of COVID-19. Gut microbiota imbalance in colorectal cancer patients may lead to the variation of OTU. Results Based on the GMrepo database, the gut microbiota of 1374 patients with colorectal neoplasms and 27,329 healthy people was analyzed to investigate the differences in the abundance of microbes between colorectal neoplasms patients and healthy people. Furthermore, We collected feces samples from 12 patients with colorectal cancer and 8 healthy people in Xiangya hospital for metabolomic analysis to investigate the potential mechanisms. Our study showed that the abundance of Blautia and Ruminococcus was significantly increased in colorectal neoplasms, which may increase the severity of COVID-19. The gender and age of patients may affect the severity of COVID-19 by shaping the gut microbiota, but the BMI of patients does not. Conclusions Our work draws an initial point that gut microbiota imbalance is a risk factor of COVID-19 mortality and gut microbiota may provide a new therapeutic avenue for colorectal cancer patients.
format	article
author	Changjing Cai Xiangyang Zhang Yihan Liu Edward Shen Ziyang Feng Cao Guo Ying Han Yanhong Ouyang Hong Shen
author_facet	Changjing Cai Xiangyang Zhang Yihan Liu Edward Shen Ziyang Feng Cao Guo Ying Han Yanhong Ouyang Hong Shen
author_sort	Changjing Cai
title	Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality
title_short	Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality
title_full	Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality
title_fullStr	Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality
title_full_unstemmed	Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality
title_sort	gut microbiota imbalance in colorectal cancer patients, the risk factor of covid-19 mortality
publisher	BMC
publishDate	2021
url	https://doaj.org/article/dfc3f10be6634ae39f2ad799499b35cf
work_keys_str_mv	AT changjingcai gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT xiangyangzhang gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT yihanliu gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT edwardshen gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT ziyangfeng gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT caoguo gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT yinghan gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT yanhongouyang gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality AT hongshen gutmicrobiotaimbalanceincolorectalcancerpatientstheriskfactorofcovid19mortality
_version_	1718372224542441472

Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality

Ejemplares similares