Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study

<i>Background and Objectives</i>: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. <i>Materials and Methods</i>: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in length) was in...

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Autores principales:	Christian Flörke, Anne-Katrin Eisenbeiß, Ulla Metz, Aydin Gülses, Yahya Acil, Jörg Wiltfang, Hendrik Naujokat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dental <i>Enterococcus faecalis</i> implant osseointegration peri-implantitis Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/dfc5606d0ab5480fb1c79fbd8b6b8657
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spelling	oai:doaj.org-article:dfc5606d0ab5480fb1c79fbd8b6b86572021-11-25T18:16:10ZIntroducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study10.3390/ma142270761996-1944https://doaj.org/article/dfc5606d0ab5480fb1c79fbd8b6b86572021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/7076https://doaj.org/toc/1996-1944<i>Background and Objectives</i>: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. <i>Materials and Methods</i>: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in length) was inserted into frontal bone (n: 12) and the basis of the corpus mandible (n: 24). Eighteen implants were contaminated via inoculation of <i>Enterococcus faecalis</i>. Six weeks after implant insertion, bone-to-implant contact (BIC) ratio, interthread bone density (ITBD), and peri-implant bone density (PIBD) were examined. In addition to that, new bone formation was assessed via fluorescence microscopy, histomorphometry, and light microscopical examinations. <i>Results</i>: Compared to the sterile implants, the contaminated implants showed significantly reduced BIC (<i>p</i> < 0.001), ITBD (<i>p</i> < 0.001), and PBD (<i>p</i> < 0.001) values. Around the sterile implants, the green and red fluorophores were overlapping and surrounding the implant without gaps, indicating healthy bone growth on the implant surface, whereas contaminated implants were surrounded by connective tissue. <i>Conclusions</i>: The current experimental model could be a feasible option to realize a significant alteration of dental-implant osseointegration and examine novel surface decontamination techniques without impairing local and systemic inflammatory complications.Christian FlörkeAnne-Katrin EisenbeißUlla MetzAydin GülsesYahya AcilJörg WiltfangHendrik NaujokatMDPI AGarticledental<i>Enterococcus faecalis</i>implantosseointegrationperi-implantitisTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 7076, p 7076 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dental <i>Enterococcus faecalis</i> implant osseointegration peri-implantitis Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	dental <i>Enterococcus faecalis</i> implant osseointegration peri-implantitis Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Christian Flörke Anne-Katrin Eisenbeiß Ulla Metz Aydin Gülses Yahya Acil Jörg Wiltfang Hendrik Naujokat Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study
description	<i>Background and Objectives</i>: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. <i>Materials and Methods</i>: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in length) was inserted into frontal bone (n: 12) and the basis of the corpus mandible (n: 24). Eighteen implants were contaminated via inoculation of <i>Enterococcus faecalis</i>. Six weeks after implant insertion, bone-to-implant contact (BIC) ratio, interthread bone density (ITBD), and peri-implant bone density (PIBD) were examined. In addition to that, new bone formation was assessed via fluorescence microscopy, histomorphometry, and light microscopical examinations. <i>Results</i>: Compared to the sterile implants, the contaminated implants showed significantly reduced BIC (<i>p</i> < 0.001), ITBD (<i>p</i> < 0.001), and PBD (<i>p</i> < 0.001) values. Around the sterile implants, the green and red fluorophores were overlapping and surrounding the implant without gaps, indicating healthy bone growth on the implant surface, whereas contaminated implants were surrounded by connective tissue. <i>Conclusions</i>: The current experimental model could be a feasible option to realize a significant alteration of dental-implant osseointegration and examine novel surface decontamination techniques without impairing local and systemic inflammatory complications.
format	article
author	Christian Flörke Anne-Katrin Eisenbeiß Ulla Metz Aydin Gülses Yahya Acil Jörg Wiltfang Hendrik Naujokat
author_facet	Christian Flörke Anne-Katrin Eisenbeiß Ulla Metz Aydin Gülses Yahya Acil Jörg Wiltfang Hendrik Naujokat
author_sort	Christian Flörke
title	Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study
title_short	Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study
title_full	Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study
title_fullStr	Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study
title_full_unstemmed	Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study
title_sort	introducing a novel experimental model for osseo-disintegration of titanium dental implants induced by monobacterial contamination: an in-vivo feasibility study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dfc5606d0ab5480fb1c79fbd8b6b8657
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Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study

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