Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.

The purpose of this study was to investigate the effect of the HXBM408 bacteria on the diversity of rat intestinal bacteria and the metabolism of soybean isoflavones. The control group was administered sterilized water and daidzein by gavage for 7 days. Conversely, the experimental group was adminis...

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Autores principales:	Li Xiaobin, Xie Jinglong, Zhao Fang, Wang Chenchen, Yang Kailun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfc5c0415c914891a2d91f49108ac4c4
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spelling	oai:doaj.org-article:dfc5c0415c914891a2d91f49108ac4c42021-12-02T20:06:58ZEffect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.1932-620310.1371/journal.pone.0253728https://doaj.org/article/dfc5c0415c914891a2d91f49108ac4c42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253728https://doaj.org/toc/1932-6203The purpose of this study was to investigate the effect of the HXBM408 bacteria on the diversity of rat intestinal bacteria and the metabolism of soybean isoflavones. The control group was administered sterilized water and daidzein by gavage for 7 days. Conversely, the experimental group was administered HXBM408 solution and daidzein by gavage for 7 days. The content of the daidzein metabolite equol in rat feces in the experimental group was significantly higher than that in the control group (P < 0.05) on the 7th and 14th days. However, the content of daidzein and its metabolites in feces was not significantly different (P > 0.05). On the 7th day, the relative abundance of Streptococcus in the feces of the experimental group was significantly higher than that of the control group (P < 0.05), but the difference disappeared over time (P > 0.05). In the intestinal digesta of rats, the proteobacteria of the experimental group was significantly lower than those of the control group (P < 0.05). HXBM408 can increase the degradation ability of soybean isoflavones in a short period after ingestion, increase the number of beneficial intestinal flora, and improve the structure of the flora.Li XiaobinXie JinglongZhao FangWang ChenchenYang KailunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253728 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Xiaobin Xie Jinglong Zhao Fang Wang Chenchen Yang Kailun Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.
description	The purpose of this study was to investigate the effect of the HXBM408 bacteria on the diversity of rat intestinal bacteria and the metabolism of soybean isoflavones. The control group was administered sterilized water and daidzein by gavage for 7 days. Conversely, the experimental group was administered HXBM408 solution and daidzein by gavage for 7 days. The content of the daidzein metabolite equol in rat feces in the experimental group was significantly higher than that in the control group (P < 0.05) on the 7th and 14th days. However, the content of daidzein and its metabolites in feces was not significantly different (P > 0.05). On the 7th day, the relative abundance of Streptococcus in the feces of the experimental group was significantly higher than that of the control group (P < 0.05), but the difference disappeared over time (P > 0.05). In the intestinal digesta of rats, the proteobacteria of the experimental group was significantly lower than those of the control group (P < 0.05). HXBM408 can increase the degradation ability of soybean isoflavones in a short period after ingestion, increase the number of beneficial intestinal flora, and improve the structure of the flora.
format	article
author	Li Xiaobin Xie Jinglong Zhao Fang Wang Chenchen Yang Kailun
author_facet	Li Xiaobin Xie Jinglong Zhao Fang Wang Chenchen Yang Kailun
author_sort	Li Xiaobin
title	Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.
title_short	Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.
title_full	Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.
title_fullStr	Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.
title_full_unstemmed	Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.
title_sort	effect of the hxbm408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dfc5c0415c914891a2d91f49108ac4c4
work_keys_str_mv	AT lixiaobin effectofthehxbm408bacteriaonratintestinalbacterialdiversityandthemetabolismofsoybeanisoflavones AT xiejinglong effectofthehxbm408bacteriaonratintestinalbacterialdiversityandthemetabolismofsoybeanisoflavones AT zhaofang effectofthehxbm408bacteriaonratintestinalbacterialdiversityandthemetabolismofsoybeanisoflavones AT wangchenchen effectofthehxbm408bacteriaonratintestinalbacterialdiversityandthemetabolismofsoybeanisoflavones AT yangkailun effectofthehxbm408bacteriaonratintestinalbacterialdiversityandthemetabolismofsoybeanisoflavones
_version_	1718375333518901248

Effect of the HXBM408 bacteria on rat intestinal bacterial diversity and the metabolism of soybean isoflavones.

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