Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Abstract Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4 −/− mice die neonatally from a defective barrier. He...

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Autores principales: Meei-Hua Lin, Fong-Fu Hsu, Debra Crumrine, Jason Meyer, Peter M. Elias, Jeffrey H. Miner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/dfc7f6f76ecc4c2db8ed01da88b91819
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