A revised biosynthetic pathway for the cofactor F420 in prokaryotes
Cofactor F420 plays crucial roles in bacterial and archaeal metabolism, but its biosynthetic pathway is not fully understood. Here, the authors present the structure of one of the enzymes and provide experimental evidence for a substantial revision of the pathway, including the identification of a n...
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Nature Portfolio
2019
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oai:doaj.org-article:dfc85bab35bc45cdb9ec5b52911c68732021-12-02T16:58:29ZA revised biosynthetic pathway for the cofactor F420 in prokaryotes10.1038/s41467-019-09534-x2041-1723https://doaj.org/article/dfc85bab35bc45cdb9ec5b52911c68732019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09534-xhttps://doaj.org/toc/2041-1723Cofactor F420 plays crucial roles in bacterial and archaeal metabolism, but its biosynthetic pathway is not fully understood. Here, the authors present the structure of one of the enzymes and provide experimental evidence for a substantial revision of the pathway, including the identification of a new intermediate.Ghader BashiriJames AntoneyEhab N. M. JirgisMihir V. ShahBlair NeyJanine CoppStephanie M. StuteleySreevalsan SreebhavanBrian PalmerMartin MiddleditchNobuhiko TokurikiChris GreeningColin ScottEdward N. BakerColin J. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ghader Bashiri James Antoney Ehab N. M. Jirgis Mihir V. Shah Blair Ney Janine Copp Stephanie M. Stuteley Sreevalsan Sreebhavan Brian Palmer Martin Middleditch Nobuhiko Tokuriki Chris Greening Colin Scott Edward N. Baker Colin J. Jackson A revised biosynthetic pathway for the cofactor F420 in prokaryotes |
| description |
Cofactor F420 plays crucial roles in bacterial and archaeal metabolism, but its biosynthetic pathway is not fully understood. Here, the authors present the structure of one of the enzymes and provide experimental evidence for a substantial revision of the pathway, including the identification of a new intermediate. |
| format |
article |
| author |
Ghader Bashiri James Antoney Ehab N. M. Jirgis Mihir V. Shah Blair Ney Janine Copp Stephanie M. Stuteley Sreevalsan Sreebhavan Brian Palmer Martin Middleditch Nobuhiko Tokuriki Chris Greening Colin Scott Edward N. Baker Colin J. Jackson |
| author_facet |
Ghader Bashiri James Antoney Ehab N. M. Jirgis Mihir V. Shah Blair Ney Janine Copp Stephanie M. Stuteley Sreevalsan Sreebhavan Brian Palmer Martin Middleditch Nobuhiko Tokuriki Chris Greening Colin Scott Edward N. Baker Colin J. Jackson |
| author_sort |
Ghader Bashiri |
| title |
A revised biosynthetic pathway for the cofactor F420 in prokaryotes |
| title_short |
A revised biosynthetic pathway for the cofactor F420 in prokaryotes |
| title_full |
A revised biosynthetic pathway for the cofactor F420 in prokaryotes |
| title_fullStr |
A revised biosynthetic pathway for the cofactor F420 in prokaryotes |
| title_full_unstemmed |
A revised biosynthetic pathway for the cofactor F420 in prokaryotes |
| title_sort |
revised biosynthetic pathway for the cofactor f420 in prokaryotes |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/dfc85bab35bc45cdb9ec5b52911c6873 |
| work_keys_str_mv |
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