Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum

Abstract Lactiplantibacillus plantarum, previously named “Lactobacillus plantarum,” is found in a wide variety of environments exhibiting a high level of intraspecies genetic diversity. To investigate the strain diversity, we performed comparative genomic analyses of the 54 complete genome sequences...

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Autores principales:	Sungmi Choi, Min-gyung Baek, Myung-Jun Chung, Sanghyun Lim, Hana Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfcbcfd52ca74421968052d55955e23e
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spelling	oai:doaj.org-article:dfcbcfd52ca74421968052d55955e23e2021-12-02T18:37:09ZDistribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum10.1038/s41598-021-99683-12045-2322https://doaj.org/article/dfcbcfd52ca74421968052d55955e23e2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99683-1https://doaj.org/toc/2045-2322Abstract Lactiplantibacillus plantarum, previously named “Lactobacillus plantarum,” is found in a wide variety of environments exhibiting a high level of intraspecies genetic diversity. To investigate the strain diversity, we performed comparative genomic analyses of the 54 complete genome sequences. The results revealed that L. plantarum subsp. plantarum was split into three lineages, A, B and C. Of the genes beneficial for probiotic activity, only those associated with the biosynthesis of plantaricin (Pln), an L. plantarum-specific bacteriocin, were found to be significantly different among the lineages. The genes related to the biosynthesis of plnE/F were conserved throughout the three lineages, whereas the outgroups did not possess any Pln-producing genes. In lineage C, the deepest and ancestral type branch, plnE/F genes, were well conserved. In lineage B, loss of gene function was observed due to mobile elements in the pln loci. In lineage A, most strains were predicted to produce more than one type of Pln by possessing diverse Pln-encoding genes. These results showed the presence of functional diversity arising from the trifurcating evolution in L. plantarum subsp. plantarum and demonstrated that Pln is an indicator for differentiating the three lineages.Sungmi ChoiMin-gyung BaekMyung-Jun ChungSanghyun LimHana YiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sungmi Choi Min-gyung Baek Myung-Jun Chung Sanghyun Lim Hana Yi Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum
description	Abstract Lactiplantibacillus plantarum, previously named “Lactobacillus plantarum,” is found in a wide variety of environments exhibiting a high level of intraspecies genetic diversity. To investigate the strain diversity, we performed comparative genomic analyses of the 54 complete genome sequences. The results revealed that L. plantarum subsp. plantarum was split into three lineages, A, B and C. Of the genes beneficial for probiotic activity, only those associated with the biosynthesis of plantaricin (Pln), an L. plantarum-specific bacteriocin, were found to be significantly different among the lineages. The genes related to the biosynthesis of plnE/F were conserved throughout the three lineages, whereas the outgroups did not possess any Pln-producing genes. In lineage C, the deepest and ancestral type branch, plnE/F genes, were well conserved. In lineage B, loss of gene function was observed due to mobile elements in the pln loci. In lineage A, most strains were predicted to produce more than one type of Pln by possessing diverse Pln-encoding genes. These results showed the presence of functional diversity arising from the trifurcating evolution in L. plantarum subsp. plantarum and demonstrated that Pln is an indicator for differentiating the three lineages.
format	article
author	Sungmi Choi Min-gyung Baek Myung-Jun Chung Sanghyun Lim Hana Yi
author_facet	Sungmi Choi Min-gyung Baek Myung-Jun Chung Sanghyun Lim Hana Yi
author_sort	Sungmi Choi
title	Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum
title_short	Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum
title_full	Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum
title_fullStr	Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum
title_full_unstemmed	Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum
title_sort	distribution of bacteriocin genes in the lineages of lactiplantibacillus plantarum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dfcbcfd52ca74421968052d55955e23e
work_keys_str_mv	AT sungmichoi distributionofbacteriocingenesinthelineagesoflactiplantibacillusplantarum AT mingyungbaek distributionofbacteriocingenesinthelineagesoflactiplantibacillusplantarum AT myungjunchung distributionofbacteriocingenesinthelineagesoflactiplantibacillusplantarum AT sanghyunlim distributionofbacteriocingenesinthelineagesoflactiplantibacillusplantarum AT hanayi distributionofbacteriocingenesinthelineagesoflactiplantibacillusplantarum
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Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum

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