Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults

Idiopathic acquired aplastic anemia can be successfully treated with Anti Thymocyte Globulin (ATG)-based immune suppressive therapy and is therefore considered a T cell-mediated auto immune disease. Based on this finding, several other forms of idiopathic acquired bone marrow failure are treated wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jennifer M.-L. Tjon, Saskia M. C. Langemeijer, Constantijn J. M. Halkes
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acquired bone marrow failure aplastic anemia pure red cell aplasia amegakaryocytic thrombocytopenia pure white cell aplasia myelodysplastic syndrome Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dfced9c7352f494ba3359605390d7ce9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dfced9c7352f494ba3359605390d7ce9
record_format	dspace
spelling	oai:doaj.org-article:dfced9c7352f494ba3359605390d7ce92021-11-25T17:08:47ZAnti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults10.3390/cells101129052073-4409https://doaj.org/article/dfced9c7352f494ba3359605390d7ce92021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2905https://doaj.org/toc/2073-4409Idiopathic acquired aplastic anemia can be successfully treated with Anti Thymocyte Globulin (ATG)-based immune suppressive therapy and is therefore considered a T cell-mediated auto immune disease. Based on this finding, several other forms of idiopathic acquired bone marrow failure are treated with ATG as well. For this review, we extensively searched the present literature for evidence that ATG can lead to enduring remissions in different forms of acquired multi- or single-lineage bone marrow failure. We conclude that ATG-based therapy can lead to an enduring hematopoietic response and increased overall survival (OS) in patients with acquired aplastic aplasia. In patients with hypocellular myelodysplastic syndrome, ATG can lead to a hematological improvement without changing the OS. ATG seems less effective in acquired single-lineage failure diseases like Pure Red Cell Aplasia, Amegakaryocytic Thrombocytopenia and Pure White Cell Aplasia, suggesting a different pathogenesis in these bone marrow failure states compared to aplastic anemia. T cell depletion is hypothesized to play an important role in the beneficial effect of ATG but, as ATG is a mixture of polyclonal antibodies binding to different antigens, other anti-inflammatory or immunomodulatory effects could play a role as well.Jennifer M.-L. TjonSaskia M. C. LangemeijerConstantijn J. M. HalkesMDPI AGarticleacquired bone marrow failureaplastic anemiapure red cell aplasiaamegakaryocytic thrombocytopeniapure white cell aplasiamyelodysplastic syndromeBiology (General)QH301-705.5ENCells, Vol 10, Iss 2905, p 2905 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acquired bone marrow failure aplastic anemia pure red cell aplasia amegakaryocytic thrombocytopenia pure white cell aplasia myelodysplastic syndrome Biology (General) QH301-705.5
spellingShingle	acquired bone marrow failure aplastic anemia pure red cell aplasia amegakaryocytic thrombocytopenia pure white cell aplasia myelodysplastic syndrome Biology (General) QH301-705.5 Jennifer M.-L. Tjon Saskia M. C. Langemeijer Constantijn J. M. Halkes Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults
description	Idiopathic acquired aplastic anemia can be successfully treated with Anti Thymocyte Globulin (ATG)-based immune suppressive therapy and is therefore considered a T cell-mediated auto immune disease. Based on this finding, several other forms of idiopathic acquired bone marrow failure are treated with ATG as well. For this review, we extensively searched the present literature for evidence that ATG can lead to enduring remissions in different forms of acquired multi- or single-lineage bone marrow failure. We conclude that ATG-based therapy can lead to an enduring hematopoietic response and increased overall survival (OS) in patients with acquired aplastic aplasia. In patients with hypocellular myelodysplastic syndrome, ATG can lead to a hematological improvement without changing the OS. ATG seems less effective in acquired single-lineage failure diseases like Pure Red Cell Aplasia, Amegakaryocytic Thrombocytopenia and Pure White Cell Aplasia, suggesting a different pathogenesis in these bone marrow failure states compared to aplastic anemia. T cell depletion is hypothesized to play an important role in the beneficial effect of ATG but, as ATG is a mixture of polyclonal antibodies binding to different antigens, other anti-inflammatory or immunomodulatory effects could play a role as well.
format	article
author	Jennifer M.-L. Tjon Saskia M. C. Langemeijer Constantijn J. M. Halkes
author_facet	Jennifer M.-L. Tjon Saskia M. C. Langemeijer Constantijn J. M. Halkes
author_sort	Jennifer M.-L. Tjon
title	Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults
title_short	Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults
title_full	Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults
title_fullStr	Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults
title_full_unstemmed	Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults
title_sort	anti thymocyte globulin-based treatment for acquired bone marrow failure in adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dfced9c7352f494ba3359605390d7ce9
work_keys_str_mv	AT jennifermltjon antithymocyteglobulinbasedtreatmentforacquiredbonemarrowfailureinadults AT saskiamclangemeijer antithymocyteglobulinbasedtreatmentforacquiredbonemarrowfailureinadults AT constantijnjmhalkes antithymocyteglobulinbasedtreatmentforacquiredbonemarrowfailureinadults
_version_	1718412684296192000

Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults

Ejemplares similares