Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan

Abstract This is a systematical report on the potential health risk of heavy metals from the leather industries in Pakistan based on multiple biological matrices of the exposed workers and indoor dust samples. The adverse impacts of heavy metals on the oxidative enzyme and their risks to workers’ he...

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Autores principales:	Muhammad Junaid, Muhammad Zaffar Hashmi, Yu-Mei Tang, Riffat Naseem Malik, De-Sheng Pei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfcf0cbc620941b4a08c7c0d936d9dea
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spelling	oai:doaj.org-article:dfcf0cbc620941b4a08c7c0d936d9dea2021-12-02T12:32:18ZPotential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan10.1038/s41598-017-09075-72045-2322https://doaj.org/article/dfcf0cbc620941b4a08c7c0d936d9dea2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09075-7https://doaj.org/toc/2045-2322Abstract This is a systematical report on the potential health risk of heavy metals from the leather industries in Pakistan based on multiple biological matrices of the exposed workers and indoor dust samples. The adverse impacts of heavy metals on the oxidative enzyme and their risks to workers’ health were also explored. Our results indicated that the level of Cr in indoor industrial dust was more than twice, compared to the background household dust. Blood, urine and hair samples of exposed workers showed significantly high concentrations of heavy metals, compared to those in the control group. Superoxide dismutase (SOD) level in the blood samples expressed significant positive correlation with Cr and Ni. Total hazard quotients (HQs)/hazard index (HI) were >1, and Cr (VI) exhibited higher cancer risks than that of Cd in the exposed workers. In addition, the PCA-MLR analysis confirmed that the industrial sections; cutting, shivering/crusting, and stitching were the principal contributors of heavy metals in the biological entities of the workers. Taken together, our results highlighted the occupationally exposed groups would likely to experience the potential health risks due to excessive exposure to the heavy metals from the leather industries.Muhammad JunaidMuhammad Zaffar HashmiYu-Mei TangRiffat Naseem MalikDe-Sheng PeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhammad Junaid Muhammad Zaffar Hashmi Yu-Mei Tang Riffat Naseem Malik De-Sheng Pei Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan
description	Abstract This is a systematical report on the potential health risk of heavy metals from the leather industries in Pakistan based on multiple biological matrices of the exposed workers and indoor dust samples. The adverse impacts of heavy metals on the oxidative enzyme and their risks to workers’ health were also explored. Our results indicated that the level of Cr in indoor industrial dust was more than twice, compared to the background household dust. Blood, urine and hair samples of exposed workers showed significantly high concentrations of heavy metals, compared to those in the control group. Superoxide dismutase (SOD) level in the blood samples expressed significant positive correlation with Cr and Ni. Total hazard quotients (HQs)/hazard index (HI) were >1, and Cr (VI) exhibited higher cancer risks than that of Cd in the exposed workers. In addition, the PCA-MLR analysis confirmed that the industrial sections; cutting, shivering/crusting, and stitching were the principal contributors of heavy metals in the biological entities of the workers. Taken together, our results highlighted the occupationally exposed groups would likely to experience the potential health risks due to excessive exposure to the heavy metals from the leather industries.
format	article
author	Muhammad Junaid Muhammad Zaffar Hashmi Yu-Mei Tang Riffat Naseem Malik De-Sheng Pei
author_facet	Muhammad Junaid Muhammad Zaffar Hashmi Yu-Mei Tang Riffat Naseem Malik De-Sheng Pei
author_sort	Muhammad Junaid
title	Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan
title_short	Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan
title_full	Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan
title_fullStr	Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan
title_full_unstemmed	Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan
title_sort	potential health risk of heavy metals in the leather manufacturing industries in sialkot, pakistan
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dfcf0cbc620941b4a08c7c0d936d9dea
work_keys_str_mv	AT muhammadjunaid potentialhealthriskofheavymetalsintheleathermanufacturingindustriesinsialkotpakistan AT muhammadzaffarhashmi potentialhealthriskofheavymetalsintheleathermanufacturingindustriesinsialkotpakistan AT yumeitang potentialhealthriskofheavymetalsintheleathermanufacturingindustriesinsialkotpakistan AT riffatnaseemmalik potentialhealthriskofheavymetalsintheleathermanufacturingindustriesinsialkotpakistan AT deshengpei potentialhealthriskofheavymetalsintheleathermanufacturingindustriesinsialkotpakistan
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Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan

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