Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population

Khalid Khalaf Alharbi, Amal F Alshammary, Omar Sammar Aljabri, Imran Ali Khan Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Imran Ali KhanDepartment of Clinical Laboratory Sciences, College of Applied Medica...

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Autores principales:	Alharbi KK, Alshammary AF, Aljabri OS, Ali Khan I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obesity saa1 gene rs11603089 rs4638289 and rs7131332 polymorphisms. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/dfcf623ffc044c6e85e24f829cbd89a3
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spelling	oai:doaj.org-article:dfcf623ffc044c6e85e24f829cbd89a32021-12-02T13:39:18ZRelationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population1178-7007https://doaj.org/article/dfcf623ffc044c6e85e24f829cbd89a32021-03-01T00:00:00Zhttps://www.dovepress.com/relationship-between-serum-amyloid-a1-saa1-gene-polymorphisms-studies--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Khalid Khalaf Alharbi, Amal F Alshammary, Omar Sammar Aljabri, Imran Ali Khan Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Imran Ali KhanDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, PO Box-10219, Riyadh, 11433, Kingdom of Saudi ArabiaTel +966501112806Fax +966114693851Email imkhan@ksu.edu.saPurpose: Limited studies have shown positive and negative associations of serum amylase A1 (SAA1) gene in childhood obesity, previously showed the relation with obesity in different ethnicity. The current study therefore investigated the impact of single nucleotide polymorphisms present in the SAA1 gene on subjects of Saudi obesity.Participants and Methods: In this case–control study, we selected 140 subjects of Saudi population and categorized them into 83 cases of obesity and 57 healthy controls. Genotyping was performed with quantitative/real time-polymerase chain reaction in the SAA1 gene for rs11603089A/G, rs4638289A/T and rs7131332A/G polymorphisms.Results: In rs11603089 polymorphism, co-dominant model (AG vs AA+GG; OR-2.23 [95% CI:1.02– 4.86]; p=0.04) and rs4638289 polymorphism, a disparity in significance was observed between the homozygous variant (TT vs AA; OR-16.8 [95% CI: 2.06– 136.8]; p=0.0009), dominant model (AT+TT vs AA; OR-2.57 [95% CI: 1.28– 5.19]; p=0.007), recessive model (TT vs AA+AT; OR-11.36 [95% CI: 1.45– 89.06]; p=0.004) and allelic frequency for (T vs A: OR-2.35 [95% CI: 1.39– 3.98]; p=0.001) between the obesity cases and control subjects. However, statistical correlations did not reveal the rs7131332A/G polymorphism either (p> 0.05).Conclusion: In conclusion, rs4638289 polymorphism was associated with risk allele and dominant model with obesity subjects. Further additional studies were warranted.Keywords: obesity, SAA1 gene, rs11603089, rs4638289 and rs7131332 polymorphismsAlharbi KKAlshammary AFAljabri OSAli Khan IDove Medical Pressarticleobesitysaa1 geners11603089rs4638289 and rs7131332 polymorphisms.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 895-900 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity saa1 gene rs11603089 rs4638289 and rs7131332 polymorphisms. Specialties of internal medicine RC581-951
spellingShingle	obesity saa1 gene rs11603089 rs4638289 and rs7131332 polymorphisms. Specialties of internal medicine RC581-951 Alharbi KK Alshammary AF Aljabri OS Ali Khan I Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population
description	Khalid Khalaf Alharbi, Amal F Alshammary, Omar Sammar Aljabri, Imran Ali Khan Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Imran Ali KhanDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, PO Box-10219, Riyadh, 11433, Kingdom of Saudi ArabiaTel +966501112806Fax +966114693851Email imkhan@ksu.edu.saPurpose: Limited studies have shown positive and negative associations of serum amylase A1 (SAA1) gene in childhood obesity, previously showed the relation with obesity in different ethnicity. The current study therefore investigated the impact of single nucleotide polymorphisms present in the SAA1 gene on subjects of Saudi obesity.Participants and Methods: In this case–control study, we selected 140 subjects of Saudi population and categorized them into 83 cases of obesity and 57 healthy controls. Genotyping was performed with quantitative/real time-polymerase chain reaction in the SAA1 gene for rs11603089A/G, rs4638289A/T and rs7131332A/G polymorphisms.Results: In rs11603089 polymorphism, co-dominant model (AG vs AA+GG; OR-2.23 [95% CI:1.02– 4.86]; p=0.04) and rs4638289 polymorphism, a disparity in significance was observed between the homozygous variant (TT vs AA; OR-16.8 [95% CI: 2.06– 136.8]; p=0.0009), dominant model (AT+TT vs AA; OR-2.57 [95% CI: 1.28– 5.19]; p=0.007), recessive model (TT vs AA+AT; OR-11.36 [95% CI: 1.45– 89.06]; p=0.004) and allelic frequency for (T vs A: OR-2.35 [95% CI: 1.39– 3.98]; p=0.001) between the obesity cases and control subjects. However, statistical correlations did not reveal the rs7131332A/G polymorphism either (p> 0.05).Conclusion: In conclusion, rs4638289 polymorphism was associated with risk allele and dominant model with obesity subjects. Further additional studies were warranted.Keywords: obesity, SAA1 gene, rs11603089, rs4638289 and rs7131332 polymorphisms
format	article
author	Alharbi KK Alshammary AF Aljabri OS Ali Khan I
author_facet	Alharbi KK Alshammary AF Aljabri OS Ali Khan I
author_sort	Alharbi KK
title	Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population
title_short	Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population
title_full	Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population
title_fullStr	Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population
title_full_unstemmed	Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population
title_sort	relationship between serum amyloid a1 (saa1) gene polymorphisms studies with obesity in the saudi population
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/dfcf623ffc044c6e85e24f829cbd89a3
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Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population

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