Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif

Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2 +-dependent inactivation while cardiac NaV1.5 is not. Here authors use structural biology, binding and electrophysiology to parse the Ca2 +-dependent changes of CaM when bound to the NaV1.4.

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Autores principales:	Jesse B. Yoder, Manu Ben-Johny, Federica Farinelli, Lakshmi Srinivasan, Sophie R. Shoemaker, Gordon F. Tomaselli, Sandra B. Gabelli, L. Mario Amzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfd0a8426542457a852ee9eb17bcb1d2
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spelling	oai:doaj.org-article:dfd0a8426542457a852ee9eb17bcb1d22021-12-02T15:35:53ZCa2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif10.1038/s41467-019-09570-72041-1723https://doaj.org/article/dfd0a8426542457a852ee9eb17bcb1d22019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09570-7https://doaj.org/toc/2041-1723Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2 +-dependent inactivation while cardiac NaV1.5 is not. Here authors use structural biology, binding and electrophysiology to parse the Ca2 +-dependent changes of CaM when bound to the NaV1.4.Jesse B. YoderManu Ben-JohnyFederica FarinelliLakshmi SrinivasanSophie R. ShoemakerGordon F. TomaselliSandra B. GabelliL. Mario AmzelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jesse B. Yoder Manu Ben-Johny Federica Farinelli Lakshmi Srinivasan Sophie R. Shoemaker Gordon F. Tomaselli Sandra B. Gabelli L. Mario Amzel Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif
description	Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2 +-dependent inactivation while cardiac NaV1.5 is not. Here authors use structural biology, binding and electrophysiology to parse the Ca2 +-dependent changes of CaM when bound to the NaV1.4.
format	article
author	Jesse B. Yoder Manu Ben-Johny Federica Farinelli Lakshmi Srinivasan Sophie R. Shoemaker Gordon F. Tomaselli Sandra B. Gabelli L. Mario Amzel
author_facet	Jesse B. Yoder Manu Ben-Johny Federica Farinelli Lakshmi Srinivasan Sophie R. Shoemaker Gordon F. Tomaselli Sandra B. Gabelli L. Mario Amzel
author_sort	Jesse B. Yoder
title	Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif
title_short	Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif
title_full	Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif
title_fullStr	Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif
title_full_unstemmed	Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif
title_sort	ca2+-dependent regulation of sodium channels nav1.4 and nav1.5 is controlled by the post-iq motif
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dfd0a8426542457a852ee9eb17bcb1d2
work_keys_str_mv	AT jessebyoder ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif AT manubenjohny ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif AT federicafarinelli ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif AT lakshmisrinivasan ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif AT sophiershoemaker ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif AT gordonftomaselli ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif AT sandrabgabelli ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif AT lmarioamzel ca2dependentregulationofsodiumchannelsnav14andnav15iscontrolledbythepostiqmotif
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Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif

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