Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.

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Autores principales:	Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfd0ef3108b94258be603a05f7ad9bb7
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spelling	oai:doaj.org-article:dfd0ef3108b94258be603a05f7ad9bb72021-12-02T16:57:59ZNicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel10.1038/ncomms131352041-1723https://doaj.org/article/dfd0ef3108b94258be603a05f7ad9bb72016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13135https://doaj.org/toc/2041-1723TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.Awani UpadhyayAditya PisupatiTimothy JeglaMatt CrookKeith J. MickolajczykMatthew ShoreyLaura E. RohanKatherine A. BillingsMelissa M. RollsWilliam O. HancockWendy Hanna-RoseNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Awani Upadhyay Aditya Pisupati Timothy Jegla Matt Crook Keith J. Mickolajczyk Matthew Shorey Laura E. Rohan Katherine A. Billings Melissa M. Rolls William O. Hancock Wendy Hanna-Rose Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
description	TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.
format	article
author	Awani Upadhyay Aditya Pisupati Timothy Jegla Matt Crook Keith J. Mickolajczyk Matthew Shorey Laura E. Rohan Katherine A. Billings Melissa M. Rolls William O. Hancock Wendy Hanna-Rose
author_facet	Awani Upadhyay Aditya Pisupati Timothy Jegla Matt Crook Keith J. Mickolajczyk Matthew Shorey Laura E. Rohan Katherine A. Billings Melissa M. Rolls William O. Hancock Wendy Hanna-Rose
author_sort	Awani Upadhyay
title	Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
title_short	Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
title_full	Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
title_fullStr	Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
title_full_unstemmed	Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
title_sort	nicotinamide is an endogenous agonist for a c. elegans trpv osm-9 and ocr-4 channel
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dfd0ef3108b94258be603a05f7ad9bb7
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Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

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