Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer

The mechanism of how VEGF-C is regulated to promote lymphatic metastasis of oesophageal cancer is unclear. Here the authors show that nicotine prevents the mRNA decay of VEGF-C mRNA and promotes lymphatic metastasis by downregulating deubiquitinase OTUD3 and RNA binding protein ZFP36.

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Autores principales:	Meng Wang, Yue Li, Yunyun Xiao, Muwen Yang, Jinxin Chen, Yunting Jian, Xin Chen, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Chuyong Lin, Libing Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfd2bc9a8b564fdb8190206a2f1ea75e
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spelling	oai:doaj.org-article:dfd2bc9a8b564fdb8190206a2f1ea75e2021-12-05T12:21:52ZNicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer10.1038/s41467-021-27348-82041-1723https://doaj.org/article/dfd2bc9a8b564fdb8190206a2f1ea75e2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27348-8https://doaj.org/toc/2041-1723The mechanism of how VEGF-C is regulated to promote lymphatic metastasis of oesophageal cancer is unclear. Here the authors show that nicotine prevents the mRNA decay of VEGF-C mRNA and promotes lymphatic metastasis by downregulating deubiquitinase OTUD3 and RNA binding protein ZFP36.Meng WangYue LiYunyun XiaoMuwen YangJinxin ChenYunting JianXin ChenDongni ShiXiangfu ChenYing OuyangLingzhi KongXinjian HuangJiewen BaiChuyong LinLibing SongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Wang Yue Li Yunyun Xiao Muwen Yang Jinxin Chen Yunting Jian Xin Chen Dongni Shi Xiangfu Chen Ying Ouyang Lingzhi Kong Xinjian Huang Jiewen Bai Chuyong Lin Libing Song Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer
description	The mechanism of how VEGF-C is regulated to promote lymphatic metastasis of oesophageal cancer is unclear. Here the authors show that nicotine prevents the mRNA decay of VEGF-C mRNA and promotes lymphatic metastasis by downregulating deubiquitinase OTUD3 and RNA binding protein ZFP36.
format	article
author	Meng Wang Yue Li Yunyun Xiao Muwen Yang Jinxin Chen Yunting Jian Xin Chen Dongni Shi Xiangfu Chen Ying Ouyang Lingzhi Kong Xinjian Huang Jiewen Bai Chuyong Lin Libing Song
author_facet	Meng Wang Yue Li Yunyun Xiao Muwen Yang Jinxin Chen Yunting Jian Xin Chen Dongni Shi Xiangfu Chen Ying Ouyang Lingzhi Kong Xinjian Huang Jiewen Bai Chuyong Lin Libing Song
author_sort	Meng Wang
title	Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer
title_short	Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer
title_full	Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer
title_fullStr	Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer
title_full_unstemmed	Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer
title_sort	nicotine-mediated otud3 downregulation inhibits vegf-c mrna decay to promote lymphatic metastasis of human esophageal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dfd2bc9a8b564fdb8190206a2f1ea75e
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Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer

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