Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), comprised of Crohn’s disease (CD) and ulcerative colitis (UC), is a group of chronic inflammatory disorders. IBD is regarded as a severe healthcare problem worldwide, with high morbidity and lethality. So far, despite of numerous studies on this issue, the specific...

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Autores principales:	Yang Zheng, Yang Yu, Xu-Feng Chen, Sheng-Lan Yang, Xiao-Long Tang, Zheng-Guo Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	inflammatory bowel disease macrophage autophagy intestinal inflammation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/dfd4960173074c1a84b14df270e82d22
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spelling	oai:doaj.org-article:dfd4960173074c1a84b14df270e82d222021-11-30T18:58:07ZIntestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease1663-981210.3389/fphar.2021.803686https://doaj.org/article/dfd4960173074c1a84b14df270e82d222021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.803686/fullhttps://doaj.org/toc/1663-9812Inflammatory bowel disease (IBD), comprised of Crohn’s disease (CD) and ulcerative colitis (UC), is a group of chronic inflammatory disorders. IBD is regarded as a severe healthcare problem worldwide, with high morbidity and lethality. So far, despite of numerous studies on this issue, the specific mechanisms of IBD still remain unclarified and ideal treatments are not available for IBD. The intestinal mucosal barrier is vital for maintaining the function of the intestinal self-defensive system. Among all of the components, macrophage is an important one in the intestinal self-defensive system, normally protecting the gut against exotic invasion. However, the over-activation of macrophages in pathological conditions leads to the overwhelming induction of intestinal inflammatory and immune reaction, thus damaging the intestinal functions. Autophagy is an important catabolic mechanism. It has been proven to participate the regulation of various kinds of inflammation- and immune-related disorders via the regulation of inflammation in related cells. Here in this paper, we will review the role and mechanism of intestinal macrophage autophagy in IBD. In addition, several well-studied kinds of agents taking advantage of intestinal macrophage autophagy for the treatment of IBD will also be discussed. We aim to bring novel insights in the development of therapeutic strategies against IBD.Yang ZhengYang YuXu-Feng ChenSheng-Lan YangXiao-Long TangZheng-Guo XiangFrontiers Media S.A.articleinflammatory bowel diseasemacrophageautophagyintestinalinflammationTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel disease macrophage autophagy intestinal inflammation Therapeutics. Pharmacology RM1-950
spellingShingle	inflammatory bowel disease macrophage autophagy intestinal inflammation Therapeutics. Pharmacology RM1-950 Yang Zheng Yang Yu Xu-Feng Chen Sheng-Lan Yang Xiao-Long Tang Zheng-Guo Xiang Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease
description	Inflammatory bowel disease (IBD), comprised of Crohn’s disease (CD) and ulcerative colitis (UC), is a group of chronic inflammatory disorders. IBD is regarded as a severe healthcare problem worldwide, with high morbidity and lethality. So far, despite of numerous studies on this issue, the specific mechanisms of IBD still remain unclarified and ideal treatments are not available for IBD. The intestinal mucosal barrier is vital for maintaining the function of the intestinal self-defensive system. Among all of the components, macrophage is an important one in the intestinal self-defensive system, normally protecting the gut against exotic invasion. However, the over-activation of macrophages in pathological conditions leads to the overwhelming induction of intestinal inflammatory and immune reaction, thus damaging the intestinal functions. Autophagy is an important catabolic mechanism. It has been proven to participate the regulation of various kinds of inflammation- and immune-related disorders via the regulation of inflammation in related cells. Here in this paper, we will review the role and mechanism of intestinal macrophage autophagy in IBD. In addition, several well-studied kinds of agents taking advantage of intestinal macrophage autophagy for the treatment of IBD will also be discussed. We aim to bring novel insights in the development of therapeutic strategies against IBD.
format	article
author	Yang Zheng Yang Yu Xu-Feng Chen Sheng-Lan Yang Xiao-Long Tang Zheng-Guo Xiang
author_facet	Yang Zheng Yang Yu Xu-Feng Chen Sheng-Lan Yang Xiao-Long Tang Zheng-Guo Xiang
author_sort	Yang Zheng
title	Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease
title_short	Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease
title_full	Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease
title_fullStr	Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease
title_full_unstemmed	Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease
title_sort	intestinal macrophage autophagy and its pharmacological application in inflammatory bowel disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dfd4960173074c1a84b14df270e82d22
work_keys_str_mv	AT yangzheng intestinalmacrophageautophagyanditspharmacologicalapplicationininflammatoryboweldisease AT yangyu intestinalmacrophageautophagyanditspharmacologicalapplicationininflammatoryboweldisease AT xufengchen intestinalmacrophageautophagyanditspharmacologicalapplicationininflammatoryboweldisease AT shenglanyang intestinalmacrophageautophagyanditspharmacologicalapplicationininflammatoryboweldisease AT xiaolongtang intestinalmacrophageautophagyanditspharmacologicalapplicationininflammatoryboweldisease AT zhengguoxiang intestinalmacrophageautophagyanditspharmacologicalapplicationininflammatoryboweldisease
_version_	1718406355500400640

Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease

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