Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown. Here, the authors show in a murine model of ischemic stroke that inhibition of phagocytosis by MEGF10 and MERTK deletion in microglia and astrocyt...

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Autores principales: Xiaojing Shi, Longlong Luo, Jixian Wang, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon-Hyuk Lee, Hengli Tian, Zhijun Zhang, Yongting Wang, Won-Suk Chung, Yaohui Tang, Guo-Yuan Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/dfd8e1c894af4f70a1dfd17b989fbcc5
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Sumario:Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown. Here, the authors show in a murine model of ischemic stroke that inhibition of phagocytosis by MEGF10 and MERTK deletion in microglia and astrocytes attenuated damage and improved neurological outcomes by preventing synapse loss.

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