Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown. Here, the authors show in a murine model of ischemic stroke that inhibition of phagocytosis by MEGF10 and MERTK deletion in microglia and astrocyt...

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Autores principales:	Xiaojing Shi, Longlong Luo, Jixian Wang, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon-Hyuk Lee, Hengli Tian, Zhijun Zhang, Yongting Wang, Won-Suk Chung, Yaohui Tang, Guo-Yuan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfd8e1c894af4f70a1dfd17b989fbcc5
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spelling	oai:doaj.org-article:dfd8e1c894af4f70a1dfd17b989fbcc52021-11-28T12:31:01ZStroke subtype-dependent synapse elimination by reactive gliosis in mice10.1038/s41467-021-27248-x2041-1723https://doaj.org/article/dfd8e1c894af4f70a1dfd17b989fbcc52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27248-xhttps://doaj.org/toc/2041-1723Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown. Here, the authors show in a murine model of ischemic stroke that inhibition of phagocytosis by MEGF10 and MERTK deletion in microglia and astrocytes attenuated damage and improved neurological outcomes by preventing synapse loss.Xiaojing ShiLonglong LuoJixian WangHui ShenYongfang LiMuyassar MamtilahunChang LiuRubing ShiJoon-Hyuk LeeHengli TianZhijun ZhangYongting WangWon-Suk ChungYaohui TangGuo-Yuan YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaojing Shi Longlong Luo Jixian Wang Hui Shen Yongfang Li Muyassar Mamtilahun Chang Liu Rubing Shi Joon-Hyuk Lee Hengli Tian Zhijun Zhang Yongting Wang Won-Suk Chung Yaohui Tang Guo-Yuan Yang Stroke subtype-dependent synapse elimination by reactive gliosis in mice
description	Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown. Here, the authors show in a murine model of ischemic stroke that inhibition of phagocytosis by MEGF10 and MERTK deletion in microglia and astrocytes attenuated damage and improved neurological outcomes by preventing synapse loss.
format	article
author	Xiaojing Shi Longlong Luo Jixian Wang Hui Shen Yongfang Li Muyassar Mamtilahun Chang Liu Rubing Shi Joon-Hyuk Lee Hengli Tian Zhijun Zhang Yongting Wang Won-Suk Chung Yaohui Tang Guo-Yuan Yang
author_facet	Xiaojing Shi Longlong Luo Jixian Wang Hui Shen Yongfang Li Muyassar Mamtilahun Chang Liu Rubing Shi Joon-Hyuk Lee Hengli Tian Zhijun Zhang Yongting Wang Won-Suk Chung Yaohui Tang Guo-Yuan Yang
author_sort	Xiaojing Shi
title	Stroke subtype-dependent synapse elimination by reactive gliosis in mice
title_short	Stroke subtype-dependent synapse elimination by reactive gliosis in mice
title_full	Stroke subtype-dependent synapse elimination by reactive gliosis in mice
title_fullStr	Stroke subtype-dependent synapse elimination by reactive gliosis in mice
title_full_unstemmed	Stroke subtype-dependent synapse elimination by reactive gliosis in mice
title_sort	stroke subtype-dependent synapse elimination by reactive gliosis in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dfd8e1c894af4f70a1dfd17b989fbcc5
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Stroke subtype-dependent synapse elimination by reactive gliosis in mice

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