Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials

Botanical supplements with broad traditional and medicinal uses represent an area of growing importance for American health management; 25% of U.S. adults use dietary supplements daily and collectively spent over $9. 5 billion in 2019 in herbal and botanical supplements alone. To understand how natu...

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Autores principales:	Evelyn J. Abraham, Joshua J. Kellogg
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metabolomics adulteration multi-omics dietary supplements biochemometrics chemometrics Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/dfda14ce644d41dca2221072f9c91889
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spelling	oai:doaj.org-article:dfda14ce644d41dca2221072f9c918892021-12-01T09:15:35ZChemometric-Guided Approaches for Profiling and Authenticating Botanical Materials2296-861X10.3389/fnut.2021.780228https://doaj.org/article/dfda14ce644d41dca2221072f9c918892021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.780228/fullhttps://doaj.org/toc/2296-861XBotanical supplements with broad traditional and medicinal uses represent an area of growing importance for American health management; 25% of U.S. adults use dietary supplements daily and collectively spent over $9. 5 billion in 2019 in herbal and botanical supplements alone. To understand how natural products benefit human health and determine potential safety concerns, careful in vitro, in vivo, and clinical studies are required. However, botanicals are innately complex systems, with complicated compositions that defy many standard analytical approaches and fluctuate based upon a plethora of factors, including genetics, growth conditions, and harvesting/processing procedures. Robust studies rely upon accurate identification of the plant material, and botanicals' increasing economic and health importance demand reproducible sourcing, as well as assessment of contamination or adulteration. These quality control needs for botanical products remain a significant problem plaguing researchers in academia as well as the supplement industry, thus posing a risk to consumers and possibly rendering clinical data irreproducible and/or irrelevant. Chemometric approaches that analyze the small molecule composition of materials provide a reliable and high-throughput avenue for botanical authentication. This review emphasizes the need for consistent material and provides insight into the roles of various modern chemometric analyses in evaluating and authenticating botanicals, focusing on advanced methodologies, including targeted and untargeted metabolite analysis, as well as the role of multivariate statistical modeling and machine learning in phytochemical characterization. Furthermore, we will discuss how chemometric approaches can be integrated with orthogonal techniques to provide a more robust approach to authentication, and provide directions for future research.Evelyn J. AbrahamJoshua J. KelloggJoshua J. KelloggFrontiers Media S.A.articlemetabolomicsadulterationmulti-omicsdietary supplementsbiochemometricschemometricsNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics adulteration multi-omics dietary supplements biochemometrics chemometrics Nutrition. Foods and food supply TX341-641
spellingShingle	metabolomics adulteration multi-omics dietary supplements biochemometrics chemometrics Nutrition. Foods and food supply TX341-641 Evelyn J. Abraham Joshua J. Kellogg Joshua J. Kellogg Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
description	Botanical supplements with broad traditional and medicinal uses represent an area of growing importance for American health management; 25% of U.S. adults use dietary supplements daily and collectively spent over $9. 5 billion in 2019 in herbal and botanical supplements alone. To understand how natural products benefit human health and determine potential safety concerns, careful in vitro, in vivo, and clinical studies are required. However, botanicals are innately complex systems, with complicated compositions that defy many standard analytical approaches and fluctuate based upon a plethora of factors, including genetics, growth conditions, and harvesting/processing procedures. Robust studies rely upon accurate identification of the plant material, and botanicals' increasing economic and health importance demand reproducible sourcing, as well as assessment of contamination or adulteration. These quality control needs for botanical products remain a significant problem plaguing researchers in academia as well as the supplement industry, thus posing a risk to consumers and possibly rendering clinical data irreproducible and/or irrelevant. Chemometric approaches that analyze the small molecule composition of materials provide a reliable and high-throughput avenue for botanical authentication. This review emphasizes the need for consistent material and provides insight into the roles of various modern chemometric analyses in evaluating and authenticating botanicals, focusing on advanced methodologies, including targeted and untargeted metabolite analysis, as well as the role of multivariate statistical modeling and machine learning in phytochemical characterization. Furthermore, we will discuss how chemometric approaches can be integrated with orthogonal techniques to provide a more robust approach to authentication, and provide directions for future research.
format	article
author	Evelyn J. Abraham Joshua J. Kellogg Joshua J. Kellogg
author_facet	Evelyn J. Abraham Joshua J. Kellogg Joshua J. Kellogg
author_sort	Evelyn J. Abraham
title	Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
title_short	Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
title_full	Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
title_fullStr	Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
title_full_unstemmed	Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
title_sort	chemometric-guided approaches for profiling and authenticating botanical materials
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dfda14ce644d41dca2221072f9c91889
work_keys_str_mv	AT evelynjabraham chemometricguidedapproachesforprofilingandauthenticatingbotanicalmaterials AT joshuajkellogg chemometricguidedapproachesforprofilingandauthenticatingbotanicalmaterials AT joshuajkellogg chemometricguidedapproachesforprofilingandauthenticatingbotanicalmaterials
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Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials

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