Molecularly imprinted polymer-based sensors for cancer biomarker detection

Ultrasensitive, quick, and non-invasive recognition of biomarkers is very useful for detection, screening, and management of cancer effectively. In this regard, there have been enormous number of articles published each year comprising natural biomolecules e.g., antibodies, enzymes, receptors and ap...

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Autores principales:	Snehasis Bhakta, Prashant Mishra
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cancer biomarkers Molecular imprinting Artificial antibodies Sensors Polymerization Instruments and machines QA71-90
Acceso en línea:	https://doaj.org/article/dfdba2bf08b74386a1b02c159084c7b9
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spelling	oai:doaj.org-article:dfdba2bf08b74386a1b02c159084c7b92021-11-28T04:38:19ZMolecularly imprinted polymer-based sensors for cancer biomarker detection2666-053910.1016/j.snr.2021.100061https://doaj.org/article/dfdba2bf08b74386a1b02c159084c7b92021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666053921000369https://doaj.org/toc/2666-0539Ultrasensitive, quick, and non-invasive recognition of biomarkers is very useful for detection, screening, and management of cancer effectively. In this regard, there have been enormous number of articles published each year comprising natural biomolecules e.g., antibodies, enzymes, receptors and aptamers as a recognition element of sensors for the detection of cancer biomarkers. However, due to stability issue and high-cost of natural biomolecules, polymeric material-based recognition element involving molecular imprinting has drawn a huge attention over the last couple of decades. The molecularly imprinted polymers (MIPs), also known as “artificial antibodies”, show sensitivity comparable to natural receptors. This review aims to deliver an insight and potential application of the MIPs towards cancer biomarker detection methods. Some discussion about classical recognition elements is also included here for better understanding the biomimicking approach. Many industries have already proved the potential of the new alterative sensing platform and if some of the drawbacks can be addressed carefully during the synthesis of the MIPs, we hope to see MIP-based diagnostic kits for cancer detection. The review is aimed to help the readers and the researchers to understand the potential of MIPs in cancer biomarker detection as well as recognition element for sensors.Snehasis BhaktaPrashant MishraElsevierarticleCancer biomarkersMolecular imprintingArtificial antibodiesSensorsPolymerizationInstruments and machinesQA71-90ENSensors and Actuators Reports, Vol 3, Iss , Pp 100061- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer biomarkers Molecular imprinting Artificial antibodies Sensors Polymerization Instruments and machines QA71-90
spellingShingle	Cancer biomarkers Molecular imprinting Artificial antibodies Sensors Polymerization Instruments and machines QA71-90 Snehasis Bhakta Prashant Mishra Molecularly imprinted polymer-based sensors for cancer biomarker detection
description	Ultrasensitive, quick, and non-invasive recognition of biomarkers is very useful for detection, screening, and management of cancer effectively. In this regard, there have been enormous number of articles published each year comprising natural biomolecules e.g., antibodies, enzymes, receptors and aptamers as a recognition element of sensors for the detection of cancer biomarkers. However, due to stability issue and high-cost of natural biomolecules, polymeric material-based recognition element involving molecular imprinting has drawn a huge attention over the last couple of decades. The molecularly imprinted polymers (MIPs), also known as “artificial antibodies”, show sensitivity comparable to natural receptors. This review aims to deliver an insight and potential application of the MIPs towards cancer biomarker detection methods. Some discussion about classical recognition elements is also included here for better understanding the biomimicking approach. Many industries have already proved the potential of the new alterative sensing platform and if some of the drawbacks can be addressed carefully during the synthesis of the MIPs, we hope to see MIP-based diagnostic kits for cancer detection. The review is aimed to help the readers and the researchers to understand the potential of MIPs in cancer biomarker detection as well as recognition element for sensors.
format	article
author	Snehasis Bhakta Prashant Mishra
author_facet	Snehasis Bhakta Prashant Mishra
author_sort	Snehasis Bhakta
title	Molecularly imprinted polymer-based sensors for cancer biomarker detection
title_short	Molecularly imprinted polymer-based sensors for cancer biomarker detection
title_full	Molecularly imprinted polymer-based sensors for cancer biomarker detection
title_fullStr	Molecularly imprinted polymer-based sensors for cancer biomarker detection
title_full_unstemmed	Molecularly imprinted polymer-based sensors for cancer biomarker detection
title_sort	molecularly imprinted polymer-based sensors for cancer biomarker detection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/dfdba2bf08b74386a1b02c159084c7b9
work_keys_str_mv	AT snehasisbhakta molecularlyimprintedpolymerbasedsensorsforcancerbiomarkerdetection AT prashantmishra molecularlyimprintedpolymerbasedsensorsforcancerbiomarkerdetection
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Molecularly imprinted polymer-based sensors for cancer biomarker detection

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