Intestinal Barrier, Claudins and Mycotoxins

The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact both on human and animal health. It was postu...

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Autores principales:	Marta Justyna Kozieł, Maksymilian Ziaja, Agnieszka Wanda Piastowska-Ciesielska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	claudins mycotoxins intestinal barrier tight junctions Medicine R
Acceso en línea:	https://doaj.org/article/dfdbafc914a940bf8ced8189c55717dd
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spelling	oai:doaj.org-article:dfdbafc914a940bf8ced8189c55717dd2021-11-25T19:08:36ZIntestinal Barrier, Claudins and Mycotoxins10.3390/toxins131107582072-6651https://doaj.org/article/dfdbafc914a940bf8ced8189c55717dd2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/758https://doaj.org/toc/2072-6651The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact both on human and animal health. It was postulated that various mycotoxins may affect homeostasis by disturbing the intestinal barrier. Claudins are proteins that are involved in creating tight junctions between epithelial cells. A growing body of evidence underlines their role in molecular response to mycotoxin-induced cytotoxicity. This review summarizes the information connected with claudins, their association with an intestinal barrier, physiological conditions in general, and with gastrointestinal cancers. Moreover, this review also includes information about the changes in claudin expression upon exposition to various mycotoxins.Marta Justyna KoziełMaksymilian ZiajaAgnieszka Wanda Piastowska-CiesielskaMDPI AGarticleclaudinsmycotoxinsintestinal barriertight junctionsMedicineRENToxins, Vol 13, Iss 758, p 758 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	claudins mycotoxins intestinal barrier tight junctions Medicine R
spellingShingle	claudins mycotoxins intestinal barrier tight junctions Medicine R Marta Justyna Kozieł Maksymilian Ziaja Agnieszka Wanda Piastowska-Ciesielska Intestinal Barrier, Claudins and Mycotoxins
description	The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact both on human and animal health. It was postulated that various mycotoxins may affect homeostasis by disturbing the intestinal barrier. Claudins are proteins that are involved in creating tight junctions between epithelial cells. A growing body of evidence underlines their role in molecular response to mycotoxin-induced cytotoxicity. This review summarizes the information connected with claudins, their association with an intestinal barrier, physiological conditions in general, and with gastrointestinal cancers. Moreover, this review also includes information about the changes in claudin expression upon exposition to various mycotoxins.
format	article
author	Marta Justyna Kozieł Maksymilian Ziaja Agnieszka Wanda Piastowska-Ciesielska
author_facet	Marta Justyna Kozieł Maksymilian Ziaja Agnieszka Wanda Piastowska-Ciesielska
author_sort	Marta Justyna Kozieł
title	Intestinal Barrier, Claudins and Mycotoxins
title_short	Intestinal Barrier, Claudins and Mycotoxins
title_full	Intestinal Barrier, Claudins and Mycotoxins
title_fullStr	Intestinal Barrier, Claudins and Mycotoxins
title_full_unstemmed	Intestinal Barrier, Claudins and Mycotoxins
title_sort	intestinal barrier, claudins and mycotoxins
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dfdbafc914a940bf8ced8189c55717dd
work_keys_str_mv	AT martajustynakozieł intestinalbarrierclaudinsandmycotoxins AT maksymilianziaja intestinalbarrierclaudinsandmycotoxins AT agnieszkawandapiastowskaciesielska intestinalbarrierclaudinsandmycotoxins
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Intestinal Barrier, Claudins and Mycotoxins

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