Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium

The co-delivery of anticancer drugs into tumor cells by a nanocarrier may provide a new paradigm in chemotherapy. Temozolomide and curcumin are anticancer drugs with a synergistic effect in the treatment of multiform glioblastoma. In this study, the entrapment and co-entrapment of temozolomide and c...

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Autores principales:	Rossella Migliore, Nicola D’Antona, Carmelo Sgarlata, Grazia M. L. Consoli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	calix[4]arene-based nanoparticle temozolomide curcumin drug delivery binding interactions drug combination Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/dfdd485792914d1890165dc2eb497691
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spelling	oai:doaj.org-article:dfdd485792914d1890165dc2eb4976912021-11-25T18:30:56ZCo-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium10.3390/nano111129302079-4991https://doaj.org/article/dfdd485792914d1890165dc2eb4976912021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2930https://doaj.org/toc/2079-4991The co-delivery of anticancer drugs into tumor cells by a nanocarrier may provide a new paradigm in chemotherapy. Temozolomide and curcumin are anticancer drugs with a synergistic effect in the treatment of multiform glioblastoma. In this study, the entrapment and co-entrapment of temozolomide and curcumin in a <i>p</i>-sulfonato-calix[4]arene nanoparticle was investigated by NMR spectroscopy, UV-vis spectrophotometry, isothermal titration calorimetry, and dynamic light scattering. Critical micellar concentration, nanoparticle size, zeta potential, drug loading percentage, and thermodynamic parameters were all consistent with a drug delivery system. Our data showed that temozolomide is hosted in the cavity of the calix[4]arene building blocks while curcumin is entrapped within the nanoparticle. Isothermal titration calorimetry evidenced that drug complexation and entrapment are entropy driven processes. The loading in the calixarene-based nanocontainer enhanced the solubility and half-life of both drugs, whose medicinal efficacy is affected by low solubility and rapid degradation. The calixarene-based nanocontainer appears to be a promising new candidate for nanocarrier-based drug combination therapy for glioblastoma.Rossella MiglioreNicola D’AntonaCarmelo SgarlataGrazia M. L. ConsoliMDPI AGarticlecalix[4]arene-based nanoparticletemozolomidecurcumindrug deliverybinding interactionsdrug combinationChemistryQD1-999ENNanomaterials, Vol 11, Iss 2930, p 2930 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calix[4]arene-based nanoparticle temozolomide curcumin drug delivery binding interactions drug combination Chemistry QD1-999
spellingShingle	calix[4]arene-based nanoparticle temozolomide curcumin drug delivery binding interactions drug combination Chemistry QD1-999 Rossella Migliore Nicola D’Antona Carmelo Sgarlata Grazia M. L. Consoli Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium
description	The co-delivery of anticancer drugs into tumor cells by a nanocarrier may provide a new paradigm in chemotherapy. Temozolomide and curcumin are anticancer drugs with a synergistic effect in the treatment of multiform glioblastoma. In this study, the entrapment and co-entrapment of temozolomide and curcumin in a <i>p</i>-sulfonato-calix[4]arene nanoparticle was investigated by NMR spectroscopy, UV-vis spectrophotometry, isothermal titration calorimetry, and dynamic light scattering. Critical micellar concentration, nanoparticle size, zeta potential, drug loading percentage, and thermodynamic parameters were all consistent with a drug delivery system. Our data showed that temozolomide is hosted in the cavity of the calix[4]arene building blocks while curcumin is entrapped within the nanoparticle. Isothermal titration calorimetry evidenced that drug complexation and entrapment are entropy driven processes. The loading in the calixarene-based nanocontainer enhanced the solubility and half-life of both drugs, whose medicinal efficacy is affected by low solubility and rapid degradation. The calixarene-based nanocontainer appears to be a promising new candidate for nanocarrier-based drug combination therapy for glioblastoma.
format	article
author	Rossella Migliore Nicola D’Antona Carmelo Sgarlata Grazia M. L. Consoli
author_facet	Rossella Migliore Nicola D’Antona Carmelo Sgarlata Grazia M. L. Consoli
author_sort	Rossella Migliore
title	Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium
title_short	Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium
title_full	Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium
title_fullStr	Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium
title_full_unstemmed	Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium
title_sort	co-loading of temozolomide and curcumin into a calix[4]arene-based nanocontainer for potential combined chemotherapy: binding features, enhanced drug solubility and stability in aqueous medium
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dfdd485792914d1890165dc2eb497691
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Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium

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