Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men

Abstract South Asians have a higher risk to develop obesity and related disorders compared to white Caucasians. This is likely in part due to their lower resting energy expenditure (REE) as related with less energy-combusting brown adipose tissue (BAT). Since overactivation of the endocannabinoid sy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vasudev Kantae, Kimberly J. Nahon, Maaike E. Straat, Leontine E. H. Bakker, Amy C. Harms, Mario van der Stelt, Thomas Hankemeier, Ingrid M. Jazet, Mariëtte R. Boon, Patrick C. N. Rensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfdffd058daa42fc9d8c34d0ba326efe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dfdffd058daa42fc9d8c34d0ba326efe
record_format	dspace
spelling	oai:doaj.org-article:dfdffd058daa42fc9d8c34d0ba326efe2021-12-02T11:52:59ZEndocannabinoid tone is higher in healthy lean South Asian than white Caucasian men10.1038/s41598-017-07980-52045-2322https://doaj.org/article/dfdffd058daa42fc9d8c34d0ba326efe2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07980-5https://doaj.org/toc/2045-2322Abstract South Asians have a higher risk to develop obesity and related disorders compared to white Caucasians. This is likely in part due to their lower resting energy expenditure (REE) as related with less energy-combusting brown adipose tissue (BAT). Since overactivation of the endocannabinoid system is associated with obesity and low BAT activity, we hypothesized that South Asians have a higher endocannabinoid tone. Healthy lean white Caucasian (n = 10) and South Asian (n = 10) men were cold-exposed to activate BAT. Before and after cooling, REE was assessed and plasma was collected for analysis of endocannabinoids and lipids. At thermoneutrality, South Asians had higher plasma levels of 2-arachidonoylglycerol (2-AG; 11.36 vs 8.19 pmol/mL, p < 0.05), N-arachidonylethanolamine (AEA; 1.04 vs 0.89 pmol/mL, p = 0.05) and arachidonic acid (AA; 23.24 vs 18.22 nmol/mL, p < 0.001). After pooling of both ethnicities, plasma 2-AG but not AEA positively correlated with triglycerides (R2 = 0.32, p < 0.05) and body fat percentage (R2 = 0.18, p < 0.05). Interestingly, AA negative correlated with REE (R2 = 0.46, p < 0.001) and positively with body fat percentage (R2 = 0.33, p < 0.01). Cooling increased endocannabinoids. In conclusion, South Asian compared to white Caucasian men have higher endocannabinoid tone. This suggests that endocannabinoids may, at least in part, underlie the disadvantageous metabolic phenotype of South Asians later in life.Vasudev KantaeKimberly J. NahonMaaike E. StraatLeontine E. H. BakkerAmy C. HarmsMario van der SteltThomas HankemeierIngrid M. JazetMariëtte R. BoonPatrick C. N. RensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vasudev Kantae Kimberly J. Nahon Maaike E. Straat Leontine E. H. Bakker Amy C. Harms Mario van der Stelt Thomas Hankemeier Ingrid M. Jazet Mariëtte R. Boon Patrick C. N. Rensen Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men
description	Abstract South Asians have a higher risk to develop obesity and related disorders compared to white Caucasians. This is likely in part due to their lower resting energy expenditure (REE) as related with less energy-combusting brown adipose tissue (BAT). Since overactivation of the endocannabinoid system is associated with obesity and low BAT activity, we hypothesized that South Asians have a higher endocannabinoid tone. Healthy lean white Caucasian (n = 10) and South Asian (n = 10) men were cold-exposed to activate BAT. Before and after cooling, REE was assessed and plasma was collected for analysis of endocannabinoids and lipids. At thermoneutrality, South Asians had higher plasma levels of 2-arachidonoylglycerol (2-AG; 11.36 vs 8.19 pmol/mL, p < 0.05), N-arachidonylethanolamine (AEA; 1.04 vs 0.89 pmol/mL, p = 0.05) and arachidonic acid (AA; 23.24 vs 18.22 nmol/mL, p < 0.001). After pooling of both ethnicities, plasma 2-AG but not AEA positively correlated with triglycerides (R2 = 0.32, p < 0.05) and body fat percentage (R2 = 0.18, p < 0.05). Interestingly, AA negative correlated with REE (R2 = 0.46, p < 0.001) and positively with body fat percentage (R2 = 0.33, p < 0.01). Cooling increased endocannabinoids. In conclusion, South Asian compared to white Caucasian men have higher endocannabinoid tone. This suggests that endocannabinoids may, at least in part, underlie the disadvantageous metabolic phenotype of South Asians later in life.
format	article
author	Vasudev Kantae Kimberly J. Nahon Maaike E. Straat Leontine E. H. Bakker Amy C. Harms Mario van der Stelt Thomas Hankemeier Ingrid M. Jazet Mariëtte R. Boon Patrick C. N. Rensen
author_facet	Vasudev Kantae Kimberly J. Nahon Maaike E. Straat Leontine E. H. Bakker Amy C. Harms Mario van der Stelt Thomas Hankemeier Ingrid M. Jazet Mariëtte R. Boon Patrick C. N. Rensen
author_sort	Vasudev Kantae
title	Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men
title_short	Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men
title_full	Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men
title_fullStr	Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men
title_full_unstemmed	Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men
title_sort	endocannabinoid tone is higher in healthy lean south asian than white caucasian men
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dfdffd058daa42fc9d8c34d0ba326efe
work_keys_str_mv	AT vasudevkantae endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT kimberlyjnahon endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT maaikeestraat endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT leontineehbakker endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT amycharms endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT mariovanderstelt endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT thomashankemeier endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT ingridmjazet endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT marietterboon endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen AT patrickcnrensen endocannabinoidtoneishigherinhealthyleansouthasianthanwhitecaucasianmen
_version_	1718394957288439808

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men

Ejemplares similares