Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System

In the present study, MCM-41 was synthesis as a carrier for poorly drugs soluble in water, by the sol-gel technique. Textural and chemical characterizations of MCM-41 were carried out by X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscope (SEM), and thermal grav...

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Autores principales:	Talib M. Albayati, Ali M. AlKafajy
Formato:	article
Lenguaje:	EN
Publicado:	Al-Khwarizmi College of Engineering – University of Baghdad 2019
Materias:	Chemical engineering TP155-156 Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/dfe04bd332574597a73a5451ddc7dfa1
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spelling	oai:doaj.org-article:dfe04bd332574597a73a5451ddc7dfa12021-12-02T08:15:56ZMesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System10.22153/kej.2019.11.0031818-11712312-0789https://doaj.org/article/dfe04bd332574597a73a5451ddc7dfa12019-05-01T00:00:00Zhttp://alkej.uobaghdad.edu.iq/index.php/alkej/article/view/496https://doaj.org/toc/1818-1171https://doaj.org/toc/2312-0789 In the present study, MCM-41 was synthesis as a carrier for poorly drugs soluble in water, by the sol-gel technique. Textural and chemical characterizations of MCM-41 were carried out by X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscope (SEM), and thermal gravimetric analysis (TGA). The experimental results were analyzed mesoporous carriers MCM-41. With maximum drug loading efficiency in MCM-41 determined to be 90.74%. The NYS released was prudently studied in simulated body fluid (SBF) pH 7.4 and the results proved that the release of NYS from MCM-41 was (87.79%) after 18 hr. The data of NYS released was found to be submitted a Weibull model with a correlation coefficient of (0.995). The Historical data experimental design facilitated the formulation and optimization of sustained discover the optimal formulation to loading drug, combine process variables, mixture components and categorical factors in one design. Talib M. AlbayatiAli M. AlKafajyAl-Khwarizmi College of Engineering – University of BaghdadarticleChemical engineeringTP155-156Engineering (General). Civil engineering (General)TA1-2040ENAl-Khawarizmi Engineering Journal, Vol 15, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemical engineering TP155-156 Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	Chemical engineering TP155-156 Engineering (General). Civil engineering (General) TA1-2040 Talib M. Albayati Ali M. AlKafajy Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System
description	In the present study, MCM-41 was synthesis as a carrier for poorly drugs soluble in water, by the sol-gel technique. Textural and chemical characterizations of MCM-41 were carried out by X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscope (SEM), and thermal gravimetric analysis (TGA). The experimental results were analyzed mesoporous carriers MCM-41. With maximum drug loading efficiency in MCM-41 determined to be 90.74%. The NYS released was prudently studied in simulated body fluid (SBF) pH 7.4 and the results proved that the release of NYS from MCM-41 was (87.79%) after 18 hr. The data of NYS released was found to be submitted a Weibull model with a correlation coefficient of (0.995). The Historical data experimental design facilitated the formulation and optimization of sustained discover the optimal formulation to loading drug, combine process variables, mixture components and categorical factors in one design.
format	article
author	Talib M. Albayati Ali M. AlKafajy
author_facet	Talib M. Albayati Ali M. AlKafajy
author_sort	Talib M. Albayati
title	Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System
title_short	Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System
title_full	Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System
title_fullStr	Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System
title_full_unstemmed	Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System
title_sort	mesoporous silica mcm-41 as a carriers material for nystatine drug in delivery system
publisher	Al-Khwarizmi College of Engineering – University of Baghdad
publishDate	2019
url	https://doaj.org/article/dfe04bd332574597a73a5451ddc7dfa1
work_keys_str_mv	AT talibmalbayati mesoporoussilicamcm41asacarriersmaterialfornystatinedrugindeliverysystem AT alimalkafajy mesoporoussilicamcm41asacarriersmaterialfornystatinedrugindeliverysystem
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Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System

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