TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human dis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daria Bottai, Wafa Frigui, Fadel Sayes, Mariagrazia Di Luca, Dalila Spadoni, Alexandre Pawlik, Marina Zoppo, Mickael Orgeur, Varun Khanna, David Hardy, Sophie Mangenot, Valerie Barbe, Claudine Medigue, Laurence Ma, Christiane Bouchier, Arianna Tavanti, Gerald Larrouy-Maumus, Roland Brosch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfe06d57f9b145fda733b5868dbc18ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dfe06d57f9b145fda733b5868dbc18ce
record_format	dspace
spelling	oai:doaj.org-article:dfe06d57f9b145fda733b5868dbc18ce2021-12-02T16:50:00ZTbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages10.1038/s41467-020-14508-52041-1723https://doaj.org/article/dfe06d57f9b145fda733b5868dbc18ce2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14508-5https://doaj.org/toc/2041-1723Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human disease progression.Daria BottaiWafa FriguiFadel SayesMariagrazia Di LucaDalila SpadoniAlexandre PawlikMarina ZoppoMickael OrgeurVarun KhannaDavid HardySophie MangenotValerie BarbeClaudine MedigueLaurence MaChristiane BouchierArianna TavantiGerald Larrouy-MaumusRoland BroschNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daria Bottai Wafa Frigui Fadel Sayes Mariagrazia Di Luca Dalila Spadoni Alexandre Pawlik Marina Zoppo Mickael Orgeur Varun Khanna David Hardy Sophie Mangenot Valerie Barbe Claudine Medigue Laurence Ma Christiane Bouchier Arianna Tavanti Gerald Larrouy-Maumus Roland Brosch TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
description	Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human disease progression.
format	article
author	Daria Bottai Wafa Frigui Fadel Sayes Mariagrazia Di Luca Dalila Spadoni Alexandre Pawlik Marina Zoppo Mickael Orgeur Varun Khanna David Hardy Sophie Mangenot Valerie Barbe Claudine Medigue Laurence Ma Christiane Bouchier Arianna Tavanti Gerald Larrouy-Maumus Roland Brosch
author_facet	Daria Bottai Wafa Frigui Fadel Sayes Mariagrazia Di Luca Dalila Spadoni Alexandre Pawlik Marina Zoppo Mickael Orgeur Varun Khanna David Hardy Sophie Mangenot Valerie Barbe Claudine Medigue Laurence Ma Christiane Bouchier Arianna Tavanti Gerald Larrouy-Maumus Roland Brosch
author_sort	Daria Bottai
title	TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
title_short	TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
title_full	TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
title_fullStr	TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
title_full_unstemmed	TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
title_sort	tbd1 deletion as a driver of the evolutionary success of modern epidemic mycobacterium tuberculosis lineages
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dfe06d57f9b145fda733b5868dbc18ce
work_keys_str_mv	AT dariabottai tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT wafafrigui tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT fadelsayes tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT mariagraziadiluca tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT dalilaspadoni tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT alexandrepawlik tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT marinazoppo tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT mickaelorgeur tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT varunkhanna tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT davidhardy tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT sophiemangenot tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT valeriebarbe tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT claudinemedigue tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT laurencema tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT christianebouchier tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT ariannatavanti tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT geraldlarrouymaumus tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages AT rolandbrosch tbd1deletionasadriveroftheevolutionarysuccessofmodernepidemicmycobacteriumtuberculosislineages
_version_	1718383189196537856

TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

Ejemplares similares