Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> during Pneumonia

Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> during Pneumonia

ABSTRACT Pathogenic bacteria require iron for replication within their host. Klebsiella pneumoniae and other Gram-negative pathogens produce the prototypical siderophore enterobactin (Ent) to scavenge iron in vivo. In response, mucosal surfaces secrete lipocalin 2 (Lcn2), an innate immune protein th...

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Autores principales: Michael A. Bachman, Steven Lenio, Lindsay Schmidt, Jennifer E. Oyler, Jeffrey N. Weiser
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2012
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/dfeb1f64b943409081300028f398ff99
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