Lipid-coated gold nanocomposites for enhanced cancer therapy

Ji Hee Kang, Young Tag Ko College of Pharmacy, Gachon University, Incheon, Republic of Korea Abstract: The aim of the work reported here was to develop lipid-coated multifunctional nanocomposites composed of drugs and nanoparticles for use in cancer therapy. We incorporated thermosensitive phospho...

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Autores principales:	Kang JH, Ko YT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dfeb8952af5d4de997bb69997daeed99
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spelling	oai:doaj.org-article:dfeb8952af5d4de997bb69997daeed992021-12-02T07:22:59ZLipid-coated gold nanocomposites for enhanced cancer therapy1178-2013https://doaj.org/article/dfeb8952af5d4de997bb69997daeed992015-08-01T00:00:00Zhttp://www.dovepress.com/lipid-coated-gold-nanocomposites-for-enhanced-cancer-therapy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ji Hee Kang, Young Tag Ko College of Pharmacy, Gachon University, Incheon, Republic of Korea Abstract: The aim of the work reported here was to develop lipid-coated multifunctional nanocomposites composed of drugs and nanoparticles for use in cancer therapy. We incorporated thermosensitive phospholipids onto the surface of anisotropic gold nanoparticles (AuNPs) to further enhance drug delivery, with possible additional applications for in vivo imaging and photothermal cancer therapy. Lipid-coated nanohybrids loaded with the drug docetaxel (DTX) were prepared by a thin-film formation, hydration, and sonication method. Nanoparticles and their composites were characterized using particle-size analysis, zeta potential measurements, transmission electron microscopy, UV-visible spectroscopy, and reverse-phase high-performance liquid chromatography, demonstrating successful loading of DTX into the lipid bilayer on the surface of the gold nanoparticles. Initial in vitro studies using breast-cancer (MCF-7) and melanoma (B16F10) cell lines demonstrated that the drug-containing nanocomposites at equivalent drug concentrations caused significant cytotoxicity compared to free DTX. Differential flow cytometry analysis confirmed the improved cellular uptake of lipid-coated nanocomposites. Our preliminary results show that DTX-loaded anionic lipid-coated gold nanorod (AL_AuNR_DTX) and cationic lipid-coated gold nanoparticle (CL_AuNP_DTX) possess effective tumor cell-suppression abilities and can therefore be considered promising chemotherapeutic agents. Further evaluation of the therapeutic efficacy of these hybrid nanoparticles combined with external near-infrared photothermal treatment is warranted to assess their synergistic anticancer actions and potential bioimaging applications. Keywords: thermosensitive lipids, gold nanorods, docetaxel, drug-containing nanocomposites, anticancerKang JHKo YTDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 33-45 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kang JH Ko YT Lipid-coated gold nanocomposites for enhanced cancer therapy
description	Ji Hee Kang, Young Tag Ko College of Pharmacy, Gachon University, Incheon, Republic of Korea Abstract: The aim of the work reported here was to develop lipid-coated multifunctional nanocomposites composed of drugs and nanoparticles for use in cancer therapy. We incorporated thermosensitive phospholipids onto the surface of anisotropic gold nanoparticles (AuNPs) to further enhance drug delivery, with possible additional applications for in vivo imaging and photothermal cancer therapy. Lipid-coated nanohybrids loaded with the drug docetaxel (DTX) were prepared by a thin-film formation, hydration, and sonication method. Nanoparticles and their composites were characterized using particle-size analysis, zeta potential measurements, transmission electron microscopy, UV-visible spectroscopy, and reverse-phase high-performance liquid chromatography, demonstrating successful loading of DTX into the lipid bilayer on the surface of the gold nanoparticles. Initial in vitro studies using breast-cancer (MCF-7) and melanoma (B16F10) cell lines demonstrated that the drug-containing nanocomposites at equivalent drug concentrations caused significant cytotoxicity compared to free DTX. Differential flow cytometry analysis confirmed the improved cellular uptake of lipid-coated nanocomposites. Our preliminary results show that DTX-loaded anionic lipid-coated gold nanorod (AL_AuNR_DTX) and cationic lipid-coated gold nanoparticle (CL_AuNP_DTX) possess effective tumor cell-suppression abilities and can therefore be considered promising chemotherapeutic agents. Further evaluation of the therapeutic efficacy of these hybrid nanoparticles combined with external near-infrared photothermal treatment is warranted to assess their synergistic anticancer actions and potential bioimaging applications. Keywords: thermosensitive lipids, gold nanorods, docetaxel, drug-containing nanocomposites, anticancer
format	article
author	Kang JH Ko YT
author_facet	Kang JH Ko YT
author_sort	Kang JH
title	Lipid-coated gold nanocomposites for enhanced cancer therapy
title_short	Lipid-coated gold nanocomposites for enhanced cancer therapy
title_full	Lipid-coated gold nanocomposites for enhanced cancer therapy
title_fullStr	Lipid-coated gold nanocomposites for enhanced cancer therapy
title_full_unstemmed	Lipid-coated gold nanocomposites for enhanced cancer therapy
title_sort	lipid-coated gold nanocomposites for enhanced cancer therapy
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/dfeb8952af5d4de997bb69997daeed99
work_keys_str_mv	AT kangjh lipidcoatedgoldnanocompositesforenhancedcancertherapy AT koyt lipidcoatedgoldnanocompositesforenhancedcancertherapy
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Lipid-coated gold nanocomposites for enhanced cancer therapy

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