Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case

Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humo...

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Autores principales:	Fabiana Gil Melgaço, Tamiris Azamor, Livia Melo Villar, Ana Paula Dinis Ano Bom, Juliana Gil Melgaço
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Crohn’s disease COVID-19 vaccine SARS-CoV-2 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/dff000ac52c94b38901a335b8c729c28
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spelling	oai:doaj.org-article:dff000ac52c94b38901a335b8c729c282021-11-25T19:12:41ZImpairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case10.3390/v131121431999-4915https://doaj.org/article/dff000ac52c94b38901a335b8c729c282021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2143https://doaj.org/toc/1999-4915Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn’s disease patient treated with Infliximab (10 mg/kg); we included comparisons with a monozygotic twin. The results showed that the Crohn’s disease’s twin (twin 2) had no antibody detection and reduced activation of CD4+ T cell responses, unlike the twin without the autoimmune disease (twin 1). Twin 2 developed antigen-specific central memory CD8+ T-cells and IFNγ production after the second dose of COVID-19 vaccination, similar to twin 1. These findings elucidated the role of T-cell immunity after COVID-19 immunization on IBD patients despite the lack of antibody production. Finally, our observation supports the consensus recommendation for IBD patients to receive COVID-19 vaccines.Fabiana Gil MelgaçoTamiris AzamorLivia Melo VillarAna Paula Dinis Ano BomJuliana Gil MelgaçoMDPI AGarticleCrohn’s diseaseCOVID-19vaccineSARS-CoV-2MicrobiologyQR1-502ENViruses, Vol 13, Iss 2143, p 2143 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crohn’s disease COVID-19 vaccine SARS-CoV-2 Microbiology QR1-502
spellingShingle	Crohn’s disease COVID-19 vaccine SARS-CoV-2 Microbiology QR1-502 Fabiana Gil Melgaço Tamiris Azamor Livia Melo Villar Ana Paula Dinis Ano Bom Juliana Gil Melgaço Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case
description	Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn’s disease patient treated with Infliximab (10 mg/kg); we included comparisons with a monozygotic twin. The results showed that the Crohn’s disease’s twin (twin 2) had no antibody detection and reduced activation of CD4+ T cell responses, unlike the twin without the autoimmune disease (twin 1). Twin 2 developed antigen-specific central memory CD8+ T-cells and IFNγ production after the second dose of COVID-19 vaccination, similar to twin 1. These findings elucidated the role of T-cell immunity after COVID-19 immunization on IBD patients despite the lack of antibody production. Finally, our observation supports the consensus recommendation for IBD patients to receive COVID-19 vaccines.
format	article
author	Fabiana Gil Melgaço Tamiris Azamor Livia Melo Villar Ana Paula Dinis Ano Bom Juliana Gil Melgaço
author_facet	Fabiana Gil Melgaço Tamiris Azamor Livia Melo Villar Ana Paula Dinis Ano Bom Juliana Gil Melgaço
author_sort	Fabiana Gil Melgaço
title	Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case
title_short	Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case
title_full	Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case
title_fullStr	Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case
title_full_unstemmed	Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case
title_sort	impairment of cd4+ t and memory b cell responses but normal memory cd8+t-cell activation on crohn’s disease after covid-19 vaccination: a twin case
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dff000ac52c94b38901a335b8c729c28
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Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case

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