Results of implementation of viral hepatitis B elimination program in the North-West Russia

Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the distri...

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Autores principales:	L. V. Lyalina, E. V. Esaulenko, E. V. Khorkova, K. E. Novak, Y. V. Ostankova, E. N. Serikova, D. V. Vasilyev, E. S. Gorziy, M. J. Butskaya, I. V. Kritskaya, L. V. Buts, E. V. Grebenkina, E. V. Baydakova, N. A. Smirnova, M. A. Krasnopyorova, N. S. Koltsov, L. M. Kotovich, E. L. Kalinina, R. R. Galimov, N. V. Kirkhar, E. A. Cherepanova, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	hepatitis b virus morbidity genotypes vaccination elimination Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/dff0fbc48a764389b521a597e300be82
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spelling	oai:doaj.org-article:dff0fbc48a764389b521a597e300be822021-11-22T07:09:56ZResults of implementation of viral hepatitis B elimination program in the North-West Russia2220-76192313-739810.15789/2220-7619-ROT-1785https://doaj.org/article/dff0fbc48a764389b521a597e300be822021-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1785https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection.L. V. LyalinaE. V. EsaulenkoE. V. KhorkovaK. E. NovakY. V. OstankovaE. N. SerikovaD. V. VasilyevE. S. GorziyM. J. ButskayaI. V. KritskayaL. V. ButsE. V. GrebenkinaE. V. BaydakovaN. A. SmirnovaM. A. KrasnopyorovaN. S. KoltsovL. M. KotovichE. L. KalininaR. R. GalimovN. V. KirkharE. A. CherepanovaAreg A. TotolianSankt-Peterburg : NIIÈM imeni Pasteraarticlehepatitis b virusmorbiditygenotypesvaccinationeliminationInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 5, Pp 875-886 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	hepatitis b virus morbidity genotypes vaccination elimination Infectious and parasitic diseases RC109-216
spellingShingle	hepatitis b virus morbidity genotypes vaccination elimination Infectious and parasitic diseases RC109-216 L. V. Lyalina E. V. Esaulenko E. V. Khorkova K. E. Novak Y. V. Ostankova E. N. Serikova D. V. Vasilyev E. S. Gorziy M. J. Butskaya I. V. Kritskaya L. V. Buts E. V. Grebenkina E. V. Baydakova N. A. Smirnova M. A. Krasnopyorova N. S. Koltsov L. M. Kotovich E. L. Kalinina R. R. Galimov N. V. Kirkhar E. A. Cherepanova Areg A. Totolian Results of implementation of viral hepatitis B elimination program in the North-West Russia
description	Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection.
format	article
author	L. V. Lyalina E. V. Esaulenko E. V. Khorkova K. E. Novak Y. V. Ostankova E. N. Serikova D. V. Vasilyev E. S. Gorziy M. J. Butskaya I. V. Kritskaya L. V. Buts E. V. Grebenkina E. V. Baydakova N. A. Smirnova M. A. Krasnopyorova N. S. Koltsov L. M. Kotovich E. L. Kalinina R. R. Galimov N. V. Kirkhar E. A. Cherepanova Areg A. Totolian
author_facet	L. V. Lyalina E. V. Esaulenko E. V. Khorkova K. E. Novak Y. V. Ostankova E. N. Serikova D. V. Vasilyev E. S. Gorziy M. J. Butskaya I. V. Kritskaya L. V. Buts E. V. Grebenkina E. V. Baydakova N. A. Smirnova M. A. Krasnopyorova N. S. Koltsov L. M. Kotovich E. L. Kalinina R. R. Galimov N. V. Kirkhar E. A. Cherepanova Areg A. Totolian
author_sort	L. V. Lyalina
title	Results of implementation of viral hepatitis B elimination program in the North-West Russia
title_short	Results of implementation of viral hepatitis B elimination program in the North-West Russia
title_full	Results of implementation of viral hepatitis B elimination program in the North-West Russia
title_fullStr	Results of implementation of viral hepatitis B elimination program in the North-West Russia
title_full_unstemmed	Results of implementation of viral hepatitis B elimination program in the North-West Russia
title_sort	results of implementation of viral hepatitis b elimination program in the north-west russia
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/dff0fbc48a764389b521a597e300be82
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Results of implementation of viral hepatitis B elimination program in the North-West Russia

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