Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.
Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as biomarkers of four different types of cancer: lung canc...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/dffb31ee89b14c958b2d13f49117c5e3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:dffb31ee89b14c958b2d13f49117c5e3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:dffb31ee89b14c958b2d13f49117c5e32021-11-18T08:41:11ZUrinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.1932-620310.1371/journal.pone.0081701https://doaj.org/article/dffb31ee89b14c958b2d13f49117c5e32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24367489/?tool=EBIhttps://doaj.org/toc/1932-6203Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer. Urine samples were purified using solid-phase extraction (SPE) and then analyzed using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The Mann-Whitney U test and Principal Component Analysis (PCA) were used to compare differences in urinary nucleosides between patients with one of four types of cancer and healthy controls. The diagnostic sensitivity of single nucleosides for different types of cancer ranged from 14% to 69%. In contrast, the diagnostic sensitivity of a set of six nucleosides ranged from 37% to 69%. The false-positive identification rate associated with the set of six nucleosides in urine was less than 2% compared with that of less than 5% for a single nucleoside. Furthermore, combining the set of six urinary nucleosides with carcinoembryonic antigen improved the diagnostic sensitivity for colon cancer. In summary, the study show that a set of six targeted nucleosides is a good diagnostic marker for breast and colon cancers but not for lung and gastric cancers.Wei-Yi HsuChao-Jung ChenYu-Chuen HuangFuu-Jen TsaiLong-Bin JengChien-Chen LaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e81701 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Wei-Yi Hsu Chao-Jung Chen Yu-Chuen Huang Fuu-Jen Tsai Long-Bin Jeng Chien-Chen Lai Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. |
| description |
Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer. Urine samples were purified using solid-phase extraction (SPE) and then analyzed using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The Mann-Whitney U test and Principal Component Analysis (PCA) were used to compare differences in urinary nucleosides between patients with one of four types of cancer and healthy controls. The diagnostic sensitivity of single nucleosides for different types of cancer ranged from 14% to 69%. In contrast, the diagnostic sensitivity of a set of six nucleosides ranged from 37% to 69%. The false-positive identification rate associated with the set of six nucleosides in urine was less than 2% compared with that of less than 5% for a single nucleoside. Furthermore, combining the set of six urinary nucleosides with carcinoembryonic antigen improved the diagnostic sensitivity for colon cancer. In summary, the study show that a set of six targeted nucleosides is a good diagnostic marker for breast and colon cancers but not for lung and gastric cancers. |
| format |
article |
| author |
Wei-Yi Hsu Chao-Jung Chen Yu-Chuen Huang Fuu-Jen Tsai Long-Bin Jeng Chien-Chen Lai |
| author_facet |
Wei-Yi Hsu Chao-Jung Chen Yu-Chuen Huang Fuu-Jen Tsai Long-Bin Jeng Chien-Chen Lai |
| author_sort |
Wei-Yi Hsu |
| title |
Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. |
| title_short |
Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. |
| title_full |
Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. |
| title_fullStr |
Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. |
| title_full_unstemmed |
Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. |
| title_sort |
urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in taiwanese. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/dffb31ee89b14c958b2d13f49117c5e3 |
| work_keys_str_mv |
AT weiyihsu urinarynucleosidesasbiomarkersofbreastcolonlungandgastriccancerintaiwanese AT chaojungchen urinarynucleosidesasbiomarkersofbreastcolonlungandgastriccancerintaiwanese AT yuchuenhuang urinarynucleosidesasbiomarkersofbreastcolonlungandgastriccancerintaiwanese AT fuujentsai urinarynucleosidesasbiomarkersofbreastcolonlungandgastriccancerintaiwanese AT longbinjeng urinarynucleosidesasbiomarkersofbreastcolonlungandgastriccancerintaiwanese AT chienchenlai urinarynucleosidesasbiomarkersofbreastcolonlungandgastriccancerintaiwanese |
| _version_ |
1718421474702786560 |