The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders

Xuan Wang, Dongyu Hua, Xiaole Tang, Shan Li, Rao Sun, Zheng Xie, Zhiqiang Zhou, Yilin Zhao, Jintao Wang, Shiyong Li, Ailin Luo Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People’s Republic of ChinaCorresp...

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Autores principales:	Wang X, Hua D, Tang X, Li S, Sun R, Xie Z, Zhou Z, Zhao Y, Wang J, Luo A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	perioperative sleep disturbance cognitive impairment postoperative delirium postoperative cognitive dysfunction neuroninflammation Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/e0025fe00acf45a59f164f15560dbb65
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spelling	oai:doaj.org-article:e0025fe00acf45a59f164f15560dbb652021-12-02T17:01:11ZThe Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders1179-1608https://doaj.org/article/e0025fe00acf45a59f164f15560dbb652021-08-01T00:00:00Zhttps://www.dovepress.com/the-role-of-perioperative-sleep-disturbance-in-postoperative-neurocogn-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Xuan Wang, Dongyu Hua, Xiaole Tang, Shan Li, Rao Sun, Zheng Xie, Zhiqiang Zhou, Yilin Zhao, Jintao Wang, Shiyong Li, Ailin Luo Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People’s Republic of ChinaCorrespondence: Shiyong Li; Ailin Luo Email shiyongli@hust.edu.cn; alluo@tjh.tjmu.edu.cnAbstract: Postoperative neurocognitive disorder (PND) increases the length of hospital stay, mortality, and risk of long-term cognitive impairment. Perioperative sleep disturbance is prevalent and commonly ignored and may increase the risk of PND. However, the role of perioperative sleep disturbances in PND remains unclear. Nocturnal sleep plays an indispensable role in learning, memory, and maintenance of cerebral microenvironmental homeostasis. Hospitalized sleep disturbances also increase the incidence of postoperative delirium and cognitive dysfunction. This review summarizes the role of perioperative sleep disturbances in PND and elucidates the potential mechanisms underlying sleep-deprivation-mediated PND. Activated neuroinflammation and oxidative stress; impaired function of the blood-brain barrier and glymphatic pathway; decreased hippocampal brain-derived neurotrophic factor, adult neurogenesis, and sirtuin1 expression; and accumulated amyloid-beta proteins are associated with PND in individuals with perioperative sleep disorders. These findings suggest that the improvement of perioperative sleep might reduce the incidence of postoperative delirium and postoperative cognitive dysfunction. Future studies should further investigate the role of perioperative sleep disturbance in PND.Keywords: perioperative sleep disturbance, cognitive impairment, postoperative delirium, postoperative cognitive dysfunction, neuroinflammationWang XHua DTang XLi SSun RXie ZZhou ZZhao YWang JLi SLuo ADove Medical Pressarticleperioperative sleep disturbancecognitive impairmentpostoperative deliriumpostoperative cognitive dysfunctionneuroninflammationPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1395-1410 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	perioperative sleep disturbance cognitive impairment postoperative delirium postoperative cognitive dysfunction neuroninflammation Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	perioperative sleep disturbance cognitive impairment postoperative delirium postoperative cognitive dysfunction neuroninflammation Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Wang X Hua D Tang X Li S Sun R Xie Z Zhou Z Zhao Y Wang J Li S Luo A The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
description	Xuan Wang, Dongyu Hua, Xiaole Tang, Shan Li, Rao Sun, Zheng Xie, Zhiqiang Zhou, Yilin Zhao, Jintao Wang, Shiyong Li, Ailin Luo Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People’s Republic of ChinaCorrespondence: Shiyong Li; Ailin Luo Email shiyongli@hust.edu.cn; alluo@tjh.tjmu.edu.cnAbstract: Postoperative neurocognitive disorder (PND) increases the length of hospital stay, mortality, and risk of long-term cognitive impairment. Perioperative sleep disturbance is prevalent and commonly ignored and may increase the risk of PND. However, the role of perioperative sleep disturbances in PND remains unclear. Nocturnal sleep plays an indispensable role in learning, memory, and maintenance of cerebral microenvironmental homeostasis. Hospitalized sleep disturbances also increase the incidence of postoperative delirium and cognitive dysfunction. This review summarizes the role of perioperative sleep disturbances in PND and elucidates the potential mechanisms underlying sleep-deprivation-mediated PND. Activated neuroinflammation and oxidative stress; impaired function of the blood-brain barrier and glymphatic pathway; decreased hippocampal brain-derived neurotrophic factor, adult neurogenesis, and sirtuin1 expression; and accumulated amyloid-beta proteins are associated with PND in individuals with perioperative sleep disorders. These findings suggest that the improvement of perioperative sleep might reduce the incidence of postoperative delirium and postoperative cognitive dysfunction. Future studies should further investigate the role of perioperative sleep disturbance in PND.Keywords: perioperative sleep disturbance, cognitive impairment, postoperative delirium, postoperative cognitive dysfunction, neuroinflammation
format	article
author	Wang X Hua D Tang X Li S Sun R Xie Z Zhou Z Zhao Y Wang J Li S Luo A
author_facet	Wang X Hua D Tang X Li S Sun R Xie Z Zhou Z Zhao Y Wang J Li S Luo A
author_sort	Wang X
title	The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_short	The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_full	The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_fullStr	The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_full_unstemmed	The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_sort	role of perioperative sleep disturbance in postoperative neurocognitive disorders
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e0025fe00acf45a59f164f15560dbb65
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The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders

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