circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway

Glioblastoma has been identified as the most common and aggressive primary brain tumor in adults. Recently, it has been found that cisplatin (DDP) treatment is a common chemotherapeutic method for GBM patients. circ_PTN (ID number: hsa_circ_0003949) is a newly found circular (circRNA) which has been...

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Autores principales:	Hongcheng Luo, Tingzhuang Yi, Deyou Huang, Xiaoping Chen, Xu Li, Qianquan Wan, Haineng Huang, Huadong Huang, Hongyu Wei, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Chuanliu Lan, Wencheng Chen, Dan Zhou, Qisheng Luo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	circ_PTN miR-542-3p PIK3R3 cisplatin-resistance glioblastoma PI3K/AKT signaling Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e003acff33174bcfa08872394e701322
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spelling	oai:doaj.org-article:e003acff33174bcfa08872394e7013222021-11-20T05:05:32Zcirc_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway2162-253110.1016/j.omtn.2021.08.034https://doaj.org/article/e003acff33174bcfa08872394e7013222021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121002298https://doaj.org/toc/2162-2531Glioblastoma has been identified as the most common and aggressive primary brain tumor in adults. Recently, it has been found that cisplatin (DDP) treatment is a common chemotherapeutic method for GBM patients. circ_PTN (ID number: hsa_circ_0003949) is a newly found circular (circRNA) which has been proved to be highly expressed in GBM cells, while its role in GBM remains unclear. Therefore, our study focused on investigating the role of circ_PTN in the DDP resistance of GBM cells. The expression of circ_PTN in DDP-sensitive and DDP-resistant GBM cells was detected in our assay. Functional experiments were utilized to unveil the effects of circ_PTN on the DDP resistance of GBM cells. Moreover, mechanism assays were conducted to confirm the mechanism of how circ_PTN affected the DDP resistance of GBM cells. According to the results, we found that circ_PTN promoted the DDP resistance of GBM cells through activation of the PI3K/AKT pathway. Moreover, circ_PTN silencing inhibited the DDP resistance of GBM tumors in vivo. To conclude, our study unveiled the influence of circ_PTN on the DDP resistance of GBM cells, which might provide a therapeutic target for GBM treatment via DDP.Hongcheng LuoTingzhuang YiDeyou HuangXiaoping ChenXu LiQianquan WanHaineng HuangHuadong HuangHongyu WeiYe SongTianshi QueRentong HuHuatuo HuangKunxiang LuoChuanyu LiChengjian QinChuanhua ZhengChuanliu LanWencheng ChenDan ZhouQisheng LuoElsevierarticlecirc_PTNmiR-542-3pPIK3R3cisplatin-resistanceglioblastomaPI3K/AKT signalingTherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1255-1269 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circ_PTN miR-542-3p PIK3R3 cisplatin-resistance glioblastoma PI3K/AKT signaling Therapeutics. Pharmacology RM1-950
spellingShingle	circ_PTN miR-542-3p PIK3R3 cisplatin-resistance glioblastoma PI3K/AKT signaling Therapeutics. Pharmacology RM1-950 Hongcheng Luo Tingzhuang Yi Deyou Huang Xiaoping Chen Xu Li Qianquan Wan Haineng Huang Huadong Huang Hongyu Wei Ye Song Tianshi Que Rentong Hu Huatuo Huang Kunxiang Luo Chuanyu Li Chengjian Qin Chuanhua Zheng Chuanliu Lan Wencheng Chen Dan Zhou Qisheng Luo circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway
description	Glioblastoma has been identified as the most common and aggressive primary brain tumor in adults. Recently, it has been found that cisplatin (DDP) treatment is a common chemotherapeutic method for GBM patients. circ_PTN (ID number: hsa_circ_0003949) is a newly found circular (circRNA) which has been proved to be highly expressed in GBM cells, while its role in GBM remains unclear. Therefore, our study focused on investigating the role of circ_PTN in the DDP resistance of GBM cells. The expression of circ_PTN in DDP-sensitive and DDP-resistant GBM cells was detected in our assay. Functional experiments were utilized to unveil the effects of circ_PTN on the DDP resistance of GBM cells. Moreover, mechanism assays were conducted to confirm the mechanism of how circ_PTN affected the DDP resistance of GBM cells. According to the results, we found that circ_PTN promoted the DDP resistance of GBM cells through activation of the PI3K/AKT pathway. Moreover, circ_PTN silencing inhibited the DDP resistance of GBM tumors in vivo. To conclude, our study unveiled the influence of circ_PTN on the DDP resistance of GBM cells, which might provide a therapeutic target for GBM treatment via DDP.
format	article
author	Hongcheng Luo Tingzhuang Yi Deyou Huang Xiaoping Chen Xu Li Qianquan Wan Haineng Huang Huadong Huang Hongyu Wei Ye Song Tianshi Que Rentong Hu Huatuo Huang Kunxiang Luo Chuanyu Li Chengjian Qin Chuanhua Zheng Chuanliu Lan Wencheng Chen Dan Zhou Qisheng Luo
author_facet	Hongcheng Luo Tingzhuang Yi Deyou Huang Xiaoping Chen Xu Li Qianquan Wan Haineng Huang Huadong Huang Hongyu Wei Ye Song Tianshi Que Rentong Hu Huatuo Huang Kunxiang Luo Chuanyu Li Chengjian Qin Chuanhua Zheng Chuanliu Lan Wencheng Chen Dan Zhou Qisheng Luo
author_sort	Hongcheng Luo
title	circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway
title_short	circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway
title_full	circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway
title_fullStr	circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway
title_full_unstemmed	circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway
title_sort	circ_ptn contributes to -cisplatin resistance in glioblastoma via pi3k/akt signaling through the mir-542-3p/pik3r3 pathway
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e003acff33174bcfa08872394e701322
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circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway

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