Canonical and noncanonical TGF-β signaling regulate fibrous tissue differentiation in the axial skeleton

Abstract Previously, we showed that embryonic deletion of TGF-β type 2 receptor in mouse sclerotome resulted in defects in fibrous connective tissues in the spine. Here we investigated how TGF-β regulates expression of fibrous markers: Scleraxis, Fibromodulin and Adamtsl2. We showed that TGF-β stimu...

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Bibliographic Details
Main Authors: Sade W. Clayton, Ga I. Ban, Cunren Liu, Rosa Serra
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
R
Q
Online Access:https://doaj.org/article/e00628fa27cf4f279488dc78fa5d23a1
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