The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune syst...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:e00651a6a48c4f899a403d6b5156aa712021-11-09T06:18:27ZThe Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer1664-322410.3389/fimmu.2021.781032https://doaj.org/article/e00651a6a48c4f899a403d6b5156aa712021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.781032/fullhttps://doaj.org/toc/1664-3224The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune system. Due to accretive evidence demonstrating that the STING pathway regulates the immune cells of the tumor microenvironment (TME), STING as a cancer biotherapy has attracted considerable attention. Pancreatic cancer, with a highly immunosuppressive TME, remains fatal cancer. STING has been applied to the treatment of pancreatic cancer through distinct strategies. This review reveals the role of STING signalling on pancreatic tumors and other diseases related to the pancreas. We then discuss new advances of STING in either monotherapy or combination methods for pancreatic cancer immunotherapy.Ghazal MohseniGhazal MohseniJuan LiAbakundana Nsenga Ariston GabrielAbakundana Nsenga Ariston GabrielLutao DuYun-shan WangChuanxin WangFrontiers Media S.A.articlepancreatic cancercGAS-STING pathwayimmunotherapytype I interferon (IFN)cytosolic DNAImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
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DOAJ |
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EN |
| topic |
pancreatic cancer cGAS-STING pathway immunotherapy type I interferon (IFN) cytosolic DNA Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
pancreatic cancer cGAS-STING pathway immunotherapy type I interferon (IFN) cytosolic DNA Immunologic diseases. Allergy RC581-607 Ghazal Mohseni Ghazal Mohseni Juan Li Abakundana Nsenga Ariston Gabriel Abakundana Nsenga Ariston Gabriel Lutao Du Yun-shan Wang Chuanxin Wang The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer |
| description |
The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune system. Due to accretive evidence demonstrating that the STING pathway regulates the immune cells of the tumor microenvironment (TME), STING as a cancer biotherapy has attracted considerable attention. Pancreatic cancer, with a highly immunosuppressive TME, remains fatal cancer. STING has been applied to the treatment of pancreatic cancer through distinct strategies. This review reveals the role of STING signalling on pancreatic tumors and other diseases related to the pancreas. We then discuss new advances of STING in either monotherapy or combination methods for pancreatic cancer immunotherapy. |
| format |
article |
| author |
Ghazal Mohseni Ghazal Mohseni Juan Li Abakundana Nsenga Ariston Gabriel Abakundana Nsenga Ariston Gabriel Lutao Du Yun-shan Wang Chuanxin Wang |
| author_facet |
Ghazal Mohseni Ghazal Mohseni Juan Li Abakundana Nsenga Ariston Gabriel Abakundana Nsenga Ariston Gabriel Lutao Du Yun-shan Wang Chuanxin Wang |
| author_sort |
Ghazal Mohseni |
| title |
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer |
| title_short |
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer |
| title_full |
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer |
| title_fullStr |
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer |
| title_full_unstemmed |
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer |
| title_sort |
function of cgas-sting pathway in treatment of pancreatic cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/e00651a6a48c4f899a403d6b5156aa71 |
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