Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes

Thirapit Subongkot,1 Tanasait Ngawhirunpat21Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, ThailandAbstract: The purpose of this s...

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Autores principales:	Subongkot T, Ngawhirunpat T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e0100849efea4142bbff776026824607
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spelling	oai:doaj.org-article:e0100849efea4142bbff7760268246072021-12-02T07:28:30ZEffect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes1178-2013https://doaj.org/article/e0100849efea4142bbff7760268246072015-07-01T00:00:00Zhttp://www.dovepress.com/effect-of-liposomal-fluidity-on-skin-permeation-of-sodium-fluorescein--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Thirapit Subongkot,1 Tanasait Ngawhirunpat21Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, ThailandAbstract: The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin labels for phospholipid bilayer fluidity at the C5 atom of the acyl chain near the polar head group (hydrophilic region) and the C16 atom of the acyl chain (lipophilic region), respectively. The electron spin resonance study revealed that Tween 20 increased the fluidity at the C5 atom of the acyl chain, whereas terpenes increased the fluidity at the C16 atom of the acyl chain of the phospholipid bilayer. The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein. Confocal laser scanning microscopy showed that ultradeformable liposomes with terpenes increase the skin penetration of sodium fluorescein by enhancing hair follicle penetration.Keywords: ultradeformable liposomes, terpenes, fluidity, electron spin resonance spectroscopy, confocal laser scanning microscopySubongkot TNgawhirunpat TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4581-4592 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Subongkot T Ngawhirunpat T Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes
description	Thirapit Subongkot,1 Tanasait Ngawhirunpat21Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, ThailandAbstract: The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin labels for phospholipid bilayer fluidity at the C5 atom of the acyl chain near the polar head group (hydrophilic region) and the C16 atom of the acyl chain (lipophilic region), respectively. The electron spin resonance study revealed that Tween 20 increased the fluidity at the C5 atom of the acyl chain, whereas terpenes increased the fluidity at the C16 atom of the acyl chain of the phospholipid bilayer. The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein. Confocal laser scanning microscopy showed that ultradeformable liposomes with terpenes increase the skin penetration of sodium fluorescein by enhancing hair follicle penetration.Keywords: ultradeformable liposomes, terpenes, fluidity, electron spin resonance spectroscopy, confocal laser scanning microscopy
format	article
author	Subongkot T Ngawhirunpat T
author_facet	Subongkot T Ngawhirunpat T
author_sort	Subongkot T
title	Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes
title_short	Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes
title_full	Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes
title_fullStr	Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes
title_full_unstemmed	Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes
title_sort	effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e0100849efea4142bbff776026824607
work_keys_str_mv	AT subongkott effectofliposomalfluidityonskinpermeationofsodiumfluoresceinentrappedinliposomes AT ngawhirunpatt effectofliposomalfluidityonskinpermeationofsodiumfluoresceinentrappedinliposomes
_version_	1718399431106101248

Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes

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