Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children

Abstract Associations between glomerular filtration rate (GFR) and cardiometabolic risk factors have been reported in adult and pediatric patients with renal disease. We aimed to assess the relationship between the estimated GFR (eGFR) and cardiometabolic risk factors in apparently healthy children....

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Autores principales:	Sílvia Xargay-Torrent, Elsa Puerto-Carranza, Irene Marcelo, Berta Mas-Parés, Ariadna Gómez-Vilarrubla, Jose-Maria Martínez-Calcerrada, Francis de Zegher, Lourdes Ibáñez, Abel López-Bermejo, Judit Bassols
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e011ab4885da4d04858c5e4c231921dc
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spelling	oai:doaj.org-article:e011ab4885da4d04858c5e4c231921dc2021-12-02T15:57:20ZEstimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children10.1038/s41598-021-91162-x2045-2322https://doaj.org/article/e011ab4885da4d04858c5e4c231921dc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91162-xhttps://doaj.org/toc/2045-2322Abstract Associations between glomerular filtration rate (GFR) and cardiometabolic risk factors have been reported in adult and pediatric patients with renal disease. We aimed to assess the relationship between the estimated GFR (eGFR) and cardiometabolic risk factors in apparently healthy children. A longitudinal study in 401 asymptomatic Caucasian children (mean age 8 years) followed up after 4 years (mean age 12 years). GFR was estimated using the pediatric form of the FAS-equation. Children were classified at baseline according to their obesity status (normal weight and overweight) and according to eGFR levels (lower, average, and higher). The association of eGFR with anthropometric data [body mass index (BMI) and waist], blood pressure [systolic (SBP) and diastolic (DBP)], metabolic parameters [glucose, insulin resistance (HOMA-IR) and serum lipids], and renal ultrasonography measurements were assessed at baseline and follow-up. Baseline eGFR associated with several cardiometabolic risk factors at follow-up including higher waist, SBP, HOMA-IR, and kidney size (all p < 0.0001) in both normal weight and overweight children. In multivariate analysis, baseline eGFR was independently associated with follow-up HOMA-IR and SBP in both normal weight and overweight subjects (model R 2: 0.188–0.444), and with follow-up BMI and waist in overweight subjects (model R 2: 0.367–0.477). Moreover, children with higher filtration rates at baseline showed higher waist, SBP, DBP, HOMA-IR and renal size both at baseline and follow-up. eGFR is related to insulin resistance, blood pressure and adiposity measures in school-age children. eGFR may help to profile the cardiometabolic risk of children.Sílvia Xargay-TorrentElsa Puerto-CarranzaIrene MarceloBerta Mas-ParésAriadna Gómez-VilarrublaJose-Maria Martínez-CalcerradaFrancis de ZegherLourdes IbáñezAbel López-BermejoJudit BassolsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sílvia Xargay-Torrent Elsa Puerto-Carranza Irene Marcelo Berta Mas-Parés Ariadna Gómez-Vilarrubla Jose-Maria Martínez-Calcerrada Francis de Zegher Lourdes Ibáñez Abel López-Bermejo Judit Bassols Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children
description	Abstract Associations between glomerular filtration rate (GFR) and cardiometabolic risk factors have been reported in adult and pediatric patients with renal disease. We aimed to assess the relationship between the estimated GFR (eGFR) and cardiometabolic risk factors in apparently healthy children. A longitudinal study in 401 asymptomatic Caucasian children (mean age 8 years) followed up after 4 years (mean age 12 years). GFR was estimated using the pediatric form of the FAS-equation. Children were classified at baseline according to their obesity status (normal weight and overweight) and according to eGFR levels (lower, average, and higher). The association of eGFR with anthropometric data [body mass index (BMI) and waist], blood pressure [systolic (SBP) and diastolic (DBP)], metabolic parameters [glucose, insulin resistance (HOMA-IR) and serum lipids], and renal ultrasonography measurements were assessed at baseline and follow-up. Baseline eGFR associated with several cardiometabolic risk factors at follow-up including higher waist, SBP, HOMA-IR, and kidney size (all p < 0.0001) in both normal weight and overweight children. In multivariate analysis, baseline eGFR was independently associated with follow-up HOMA-IR and SBP in both normal weight and overweight subjects (model R 2: 0.188–0.444), and with follow-up BMI and waist in overweight subjects (model R 2: 0.367–0.477). Moreover, children with higher filtration rates at baseline showed higher waist, SBP, DBP, HOMA-IR and renal size both at baseline and follow-up. eGFR is related to insulin resistance, blood pressure and adiposity measures in school-age children. eGFR may help to profile the cardiometabolic risk of children.
format	article
author	Sílvia Xargay-Torrent Elsa Puerto-Carranza Irene Marcelo Berta Mas-Parés Ariadna Gómez-Vilarrubla Jose-Maria Martínez-Calcerrada Francis de Zegher Lourdes Ibáñez Abel López-Bermejo Judit Bassols
author_facet	Sílvia Xargay-Torrent Elsa Puerto-Carranza Irene Marcelo Berta Mas-Parés Ariadna Gómez-Vilarrubla Jose-Maria Martínez-Calcerrada Francis de Zegher Lourdes Ibáñez Abel López-Bermejo Judit Bassols
author_sort	Sílvia Xargay-Torrent
title	Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children
title_short	Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children
title_full	Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children
title_fullStr	Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children
title_full_unstemmed	Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children
title_sort	estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e011ab4885da4d04858c5e4c231921dc
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Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children

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