Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population

Shubo Tan, Yongmao Zeng, Shiliang Kuang, Jianjun Li Department of Urology, Second Affiliated Hospital of the University of South China, Hengyang City, 421000, People’s Republic of ChinaCorrespondence: Jianjun LiDepartment of Urology, Second Affiliated Hospital of the University of South Ch...

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Autores principales:	Tan S, Zeng Y, Kuang S, Li J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	biomarker chronic kidney disease human epididymis protein 4. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e011da6aba054fd69e6f40bab55cedb4
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spelling	oai:doaj.org-article:e011da6aba054fd69e6f40bab55cedb42021-12-02T14:27:54ZSerum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population1178-7007https://doaj.org/article/e011da6aba054fd69e6f40bab55cedb42021-04-01T00:00:00Zhttps://www.dovepress.com/serum-human-epididymis-protein-4-is-a-potential-biomarker-for-early-ch-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shubo Tan, Yongmao Zeng, Shiliang Kuang, Jianjun Li Department of Urology, Second Affiliated Hospital of the University of South China, Hengyang City, 421000, People’s Republic of ChinaCorrespondence: Jianjun LiDepartment of Urology, Second Affiliated Hospital of the University of South China, No. 35, Jiefang Avenue, Zhengxiang District, Hengyang City, 421000, Hunan Province, People’s Republic of ChinaTel +861301734996Email liundefy666@126.comBackground: At present, it is difficult to clinically diagnose early chronic kidney disease (CKD). As a novel biomarker of malignancies in the female reproductive tract, the human epididymis protein 4 (HE4) has been reported to be significantly expressed in CKD patients.Aim: We sought to assess whether HE4 can be used as a potential biomarker of early-stage CKD.Methods: The association between serum HE4 levels and CKD was analyzed in a retrospective study. A cohort of 506 patients with diabetic nephropathy who were hospitalized at Weihai Central Hospital, China, from January 2016 to November 2019 were included.Results: Serum HE4 levels were increased with increasing stage of CKD and significantly elevated in patients with CKD3-5 than CKD1-2 (P< 0.001). In multivariate linear regression analyses, HE4 levels were strongly correlated with the estimated glomerular filtration rate (eGFR) in CKD patients (Model 2, P< 0.001). HE4 (area under the curve; AUC=0.934) had better diagnostic value than serum creatinine (SCr; AUC=0.770) and blood urea nitrogen (BUN; AUC=0.647) for patients with early-stage CKD (CKD1-2). Additionally, HE4 levels increased with increasing glomerular lesion (GL) and renal interstitial fibrosis (IF)/tubular atrophy (TA) scores in 51 CKD patients (P< 0.001).Conclusion: Serum HE4 levels can be positively associated with the severity of CKD and are a very valuable clinical biomarker for predicting early-stage CKD.Keywords: biomarker, chronic kidney disease, obese, human epididymis protein 4Tan SZeng YKuang SLi JDove Medical Pressarticlebiomarkerchronic kidney diseasehuman epididymis protein 4.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1601-1608 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarker chronic kidney disease human epididymis protein 4. Specialties of internal medicine RC581-951
spellingShingle	biomarker chronic kidney disease human epididymis protein 4. Specialties of internal medicine RC581-951 Tan S Zeng Y Kuang S Li J Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population
description	Shubo Tan, Yongmao Zeng, Shiliang Kuang, Jianjun Li Department of Urology, Second Affiliated Hospital of the University of South China, Hengyang City, 421000, People’s Republic of ChinaCorrespondence: Jianjun LiDepartment of Urology, Second Affiliated Hospital of the University of South China, No. 35, Jiefang Avenue, Zhengxiang District, Hengyang City, 421000, Hunan Province, People’s Republic of ChinaTel +861301734996Email liundefy666@126.comBackground: At present, it is difficult to clinically diagnose early chronic kidney disease (CKD). As a novel biomarker of malignancies in the female reproductive tract, the human epididymis protein 4 (HE4) has been reported to be significantly expressed in CKD patients.Aim: We sought to assess whether HE4 can be used as a potential biomarker of early-stage CKD.Methods: The association between serum HE4 levels and CKD was analyzed in a retrospective study. A cohort of 506 patients with diabetic nephropathy who were hospitalized at Weihai Central Hospital, China, from January 2016 to November 2019 were included.Results: Serum HE4 levels were increased with increasing stage of CKD and significantly elevated in patients with CKD3-5 than CKD1-2 (P< 0.001). In multivariate linear regression analyses, HE4 levels were strongly correlated with the estimated glomerular filtration rate (eGFR) in CKD patients (Model 2, P< 0.001). HE4 (area under the curve; AUC=0.934) had better diagnostic value than serum creatinine (SCr; AUC=0.770) and blood urea nitrogen (BUN; AUC=0.647) for patients with early-stage CKD (CKD1-2). Additionally, HE4 levels increased with increasing glomerular lesion (GL) and renal interstitial fibrosis (IF)/tubular atrophy (TA) scores in 51 CKD patients (P< 0.001).Conclusion: Serum HE4 levels can be positively associated with the severity of CKD and are a very valuable clinical biomarker for predicting early-stage CKD.Keywords: biomarker, chronic kidney disease, obese, human epididymis protein 4
format	article
author	Tan S Zeng Y Kuang S Li J
author_facet	Tan S Zeng Y Kuang S Li J
author_sort	Tan S
title	Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population
title_short	Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population
title_full	Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population
title_fullStr	Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population
title_full_unstemmed	Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population
title_sort	serum human epididymis protein 4 is a potential biomarker for early chronic kidney disease in an obese population
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e011da6aba054fd69e6f40bab55cedb4
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Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population

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