Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

Antimicrobial peptides (AMPs) are emerging as drug candidates, but the risk of pathogen resistance is not well understood. Here, the authors investigate AMP resistance evolution in E. coli, finding physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquire...

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Autores principales:	Réka Spohn, Lejla Daruka, Viktória Lázár, Ana Martins, Fanni Vidovics, Gábor Grézal, Orsolya Méhi, Bálint Kintses, Mónika Számel, Pramod K. Jangir, Bálint Csörgő, Ádám Györkei, Zoltán Bódi, Anikó Faragó, László Bodai, Imre Földesi, Diána Kata, Gergely Maróti, Bernadett Pap, Roland Wirth, Balázs Papp, Csaba Pál
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e014c0e34853487181f89fde9d5f3e38
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spelling	oai:doaj.org-article:e014c0e34853487181f89fde9d5f3e382021-12-02T16:57:30ZIntegrated evolutionary analysis reveals antimicrobial peptides with limited resistance10.1038/s41467-019-12364-62041-1723https://doaj.org/article/e014c0e34853487181f89fde9d5f3e382019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12364-6https://doaj.org/toc/2041-1723Antimicrobial peptides (AMPs) are emerging as drug candidates, but the risk of pathogen resistance is not well understood. Here, the authors investigate AMP resistance evolution in E. coli, finding physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquired resistance.Réka SpohnLejla DarukaViktória LázárAna MartinsFanni VidovicsGábor GrézalOrsolya MéhiBálint KintsesMónika SzámelPramod K. JangirBálint CsörgőÁdám GyörkeiZoltán BódiAnikó FaragóLászló BodaiImre FöldesiDiána KataGergely MarótiBernadett PapRoland WirthBalázs PappCsaba PálNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Réka Spohn Lejla Daruka Viktória Lázár Ana Martins Fanni Vidovics Gábor Grézal Orsolya Méhi Bálint Kintses Mónika Számel Pramod K. Jangir Bálint Csörgő Ádám Györkei Zoltán Bódi Anikó Faragó László Bodai Imre Földesi Diána Kata Gergely Maróti Bernadett Pap Roland Wirth Balázs Papp Csaba Pál Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
description	Antimicrobial peptides (AMPs) are emerging as drug candidates, but the risk of pathogen resistance is not well understood. Here, the authors investigate AMP resistance evolution in E. coli, finding physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquired resistance.
format	article
author	Réka Spohn Lejla Daruka Viktória Lázár Ana Martins Fanni Vidovics Gábor Grézal Orsolya Méhi Bálint Kintses Mónika Számel Pramod K. Jangir Bálint Csörgő Ádám Györkei Zoltán Bódi Anikó Faragó László Bodai Imre Földesi Diána Kata Gergely Maróti Bernadett Pap Roland Wirth Balázs Papp Csaba Pál
author_facet	Réka Spohn Lejla Daruka Viktória Lázár Ana Martins Fanni Vidovics Gábor Grézal Orsolya Méhi Bálint Kintses Mónika Számel Pramod K. Jangir Bálint Csörgő Ádám Györkei Zoltán Bódi Anikó Faragó László Bodai Imre Földesi Diána Kata Gergely Maróti Bernadett Pap Roland Wirth Balázs Papp Csaba Pál
author_sort	Réka Spohn
title	Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
title_short	Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
title_full	Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
title_fullStr	Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
title_full_unstemmed	Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
title_sort	integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e014c0e34853487181f89fde9d5f3e38
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Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

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