Characteristics of infective endocarditis in a cancer population

Background Infective endocarditis (IE) is more common in patients with cancer as compared with the general population. Due to an immunocompromised state, the need for invasive procedures, hypercoagulability and the presence of indwelling catheters, patients with cancer are particularly predisposed t...

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Autores principales:	Jose Banchs, Juhee Song, Saamir A Hassan, Cullen Grable, George M Viola, Owais Ulhaq, Corey T Jensen, Harsh Goel, Syed W Yusuf
Formato:	article
Lenguaje:	EN
Publicado:	BMJ Publishing Group 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e0175c21dcd74a5f9596d33afb63169f
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spelling	oai:doaj.org-article:e0175c21dcd74a5f9596d33afb63169f2021-11-11T09:00:08ZCharacteristics of infective endocarditis in a cancer population10.1136/openhrt-2021-0016642053-3624https://doaj.org/article/e0175c21dcd74a5f9596d33afb63169f2021-10-01T00:00:00Zhttps://openheart.bmj.com/content/8/2/e001664.fullhttps://doaj.org/toc/2053-3624Background Infective endocarditis (IE) is more common in patients with cancer as compared with the general population. Due to an immunocompromised state, the need for invasive procedures, hypercoagulability and the presence of indwelling catheters, patients with cancer are particularly predisposed to the development of IE.Objectives Limited information exists about IE in patients with cancer. We aimed to evaluate the characteristics of patients with cancer and IE at our tertiary care centre, including a comparison of the microorganisms implicated and their association with mortality.Methods A retrospective chart review of patients with cancer who had echocardiography for suspicion of endocarditis was conducted. A total of 56 patients with a confirmed diagnosis of cancer and endocarditis, based on the modified Duke criteria, were included in the study. Baseline demographics, risk factors for developing IE, echocardiography findings, microbiology and mortality data were analysed.Results Following the findings of vegetations by echocardiography, the median survival time was 8.5 months. Staphylococcus aureus was the most common organism identified as causing endocarditis. The mitral and aortic valves were the most commonly involved sites of endocarditis. Patients with S. aureus endocarditis (SAE) had a significantly poorer survival when compared with patients without SAE (p=0.0217) over the 12-month period from diagnosis of endocarditis.Conclusions Overall survival of patients with cancer and endocarditis is poor, with a worse outcome in patients with SAE.Jose BanchsJuhee SongSaamir A HassanCullen GrableGeorge M ViolaOwais UlhaqCorey T JensenHarsh GoelSyed W YusufBMJ Publishing GrouparticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENOpen Heart, Vol 8, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Jose Banchs Juhee Song Saamir A Hassan Cullen Grable George M Viola Owais Ulhaq Corey T Jensen Harsh Goel Syed W Yusuf Characteristics of infective endocarditis in a cancer population
description	Background Infective endocarditis (IE) is more common in patients with cancer as compared with the general population. Due to an immunocompromised state, the need for invasive procedures, hypercoagulability and the presence of indwelling catheters, patients with cancer are particularly predisposed to the development of IE.Objectives Limited information exists about IE in patients with cancer. We aimed to evaluate the characteristics of patients with cancer and IE at our tertiary care centre, including a comparison of the microorganisms implicated and their association with mortality.Methods A retrospective chart review of patients with cancer who had echocardiography for suspicion of endocarditis was conducted. A total of 56 patients with a confirmed diagnosis of cancer and endocarditis, based on the modified Duke criteria, were included in the study. Baseline demographics, risk factors for developing IE, echocardiography findings, microbiology and mortality data were analysed.Results Following the findings of vegetations by echocardiography, the median survival time was 8.5 months. Staphylococcus aureus was the most common organism identified as causing endocarditis. The mitral and aortic valves were the most commonly involved sites of endocarditis. Patients with S. aureus endocarditis (SAE) had a significantly poorer survival when compared with patients without SAE (p=0.0217) over the 12-month period from diagnosis of endocarditis.Conclusions Overall survival of patients with cancer and endocarditis is poor, with a worse outcome in patients with SAE.
format	article
author	Jose Banchs Juhee Song Saamir A Hassan Cullen Grable George M Viola Owais Ulhaq Corey T Jensen Harsh Goel Syed W Yusuf
author_facet	Jose Banchs Juhee Song Saamir A Hassan Cullen Grable George M Viola Owais Ulhaq Corey T Jensen Harsh Goel Syed W Yusuf
author_sort	Jose Banchs
title	Characteristics of infective endocarditis in a cancer population
title_short	Characteristics of infective endocarditis in a cancer population
title_full	Characteristics of infective endocarditis in a cancer population
title_fullStr	Characteristics of infective endocarditis in a cancer population
title_full_unstemmed	Characteristics of infective endocarditis in a cancer population
title_sort	characteristics of infective endocarditis in a cancer population
publisher	BMJ Publishing Group
publishDate	2021
url	https://doaj.org/article/e0175c21dcd74a5f9596d33afb63169f
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Characteristics of infective endocarditis in a cancer population

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