Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2

The production of specific neutralizing antibodies by individuals is thought to be the best option for reducing the number of patients with severe COVID-19, which is the reason why multiple vaccines are currently being administered worldwide. We aimed to explore the effect of revaccination with BCG,...

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Autores principales:	Espiridión Ramos-Martinez, Ramcés Falfán-Valencia, Gloria Pérez-Rubio, Warrison Athanasio Andrade, Jorge Rojas-Serrano, Enrique Ambrocio-Ortiz, Dennisse S. Galicia-Álvarez, Isaac Bárcenas-Montiel, Andrea Velasco-Medina, Guillermo Velázquez-Sámano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 BCG vaccination neutralizing antibodies Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e0180518a2dc4017a7eec43451a048f3
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spelling	oai:doaj.org-article:e0180518a2dc4017a7eec43451a048f32021-11-25T17:12:25ZEffect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-210.3390/cells101131792073-4409https://doaj.org/article/e0180518a2dc4017a7eec43451a048f32021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3179https://doaj.org/toc/2073-4409The production of specific neutralizing antibodies by individuals is thought to be the best option for reducing the number of patients with severe COVID-19, which is the reason why multiple vaccines are currently being administered worldwide. We aimed to explore the effect of revaccination with BCG, on the response to a subsequent anti-SARS-CoV-2 vaccine, in persons occupationally exposed to COVID-19 patients. Two groups of 30 randomized participants were selected: one group received a BCG revaccination, and the other group received a placebo. Subsequently, both groups were vaccinated against SARS-CoV-2. After each round of vaccination, the serum concentration of Th1/Th2 cytokines was determined. At the end of the protocol, neutralizing antibodies were determined and the HLA-DRB loci were genotyped. The participants from the BCG group and anti-SARS-CoV-2 vaccine group had increased serum cytokine concentrations (i.e., IL-1β, IL-4, IL-6, IL-12p70, IL-13, IL-18, GM-CSF, INF-γ, and TNF-α) and higher neutralizing antibody titers, compared to the group with Placebo–anti-SARS-CoV-2. Twelve HLA-DRB1 alleles were identified in the Placebo–anti-SARS-CoV-2 group, and only nine in the group revaccinated with BCG. The DRB1*04 allele exhibited increased frequency in the Placebo–anti-SARS-CoV-2 group; however, no confounding effects were found with this allele. We conclude that revaccination with BCG synergizes with subsequent vaccination against SARS-CoV-2 in occupationally exposed personnel.Espiridión Ramos-MartinezRamcés Falfán-ValenciaGloria Pérez-RubioWarrison Athanasio AndradeJorge Rojas-SerranoEnrique Ambrocio-OrtizDennisse S. Galicia-ÁlvarezIsaac Bárcenas-MontielAndrea Velasco-MedinaGuillermo Velázquez-SámanoMDPI AGarticleSARS-CoV-2COVID-19BCGvaccinationneutralizing antibodiesBiology (General)QH301-705.5ENCells, Vol 10, Iss 3179, p 3179 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 BCG vaccination neutralizing antibodies Biology (General) QH301-705.5
spellingShingle	SARS-CoV-2 COVID-19 BCG vaccination neutralizing antibodies Biology (General) QH301-705.5 Espiridión Ramos-Martinez Ramcés Falfán-Valencia Gloria Pérez-Rubio Warrison Athanasio Andrade Jorge Rojas-Serrano Enrique Ambrocio-Ortiz Dennisse S. Galicia-Álvarez Isaac Bárcenas-Montiel Andrea Velasco-Medina Guillermo Velázquez-Sámano Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2
description	The production of specific neutralizing antibodies by individuals is thought to be the best option for reducing the number of patients with severe COVID-19, which is the reason why multiple vaccines are currently being administered worldwide. We aimed to explore the effect of revaccination with BCG, on the response to a subsequent anti-SARS-CoV-2 vaccine, in persons occupationally exposed to COVID-19 patients. Two groups of 30 randomized participants were selected: one group received a BCG revaccination, and the other group received a placebo. Subsequently, both groups were vaccinated against SARS-CoV-2. After each round of vaccination, the serum concentration of Th1/Th2 cytokines was determined. At the end of the protocol, neutralizing antibodies were determined and the HLA-DRB loci were genotyped. The participants from the BCG group and anti-SARS-CoV-2 vaccine group had increased serum cytokine concentrations (i.e., IL-1β, IL-4, IL-6, IL-12p70, IL-13, IL-18, GM-CSF, INF-γ, and TNF-α) and higher neutralizing antibody titers, compared to the group with Placebo–anti-SARS-CoV-2. Twelve HLA-DRB1 alleles were identified in the Placebo–anti-SARS-CoV-2 group, and only nine in the group revaccinated with BCG. The DRB1*04 allele exhibited increased frequency in the Placebo–anti-SARS-CoV-2 group; however, no confounding effects were found with this allele. We conclude that revaccination with BCG synergizes with subsequent vaccination against SARS-CoV-2 in occupationally exposed personnel.
format	article
author	Espiridión Ramos-Martinez Ramcés Falfán-Valencia Gloria Pérez-Rubio Warrison Athanasio Andrade Jorge Rojas-Serrano Enrique Ambrocio-Ortiz Dennisse S. Galicia-Álvarez Isaac Bárcenas-Montiel Andrea Velasco-Medina Guillermo Velázquez-Sámano
author_facet	Espiridión Ramos-Martinez Ramcés Falfán-Valencia Gloria Pérez-Rubio Warrison Athanasio Andrade Jorge Rojas-Serrano Enrique Ambrocio-Ortiz Dennisse S. Galicia-Álvarez Isaac Bárcenas-Montiel Andrea Velasco-Medina Guillermo Velázquez-Sámano
author_sort	Espiridión Ramos-Martinez
title	Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2
title_short	Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2
title_full	Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2
title_fullStr	Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2
title_full_unstemmed	Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2
title_sort	effect of bcg revaccination on occupationally exposed medical personnel vaccinated against sars-cov-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e0180518a2dc4017a7eec43451a048f3
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Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2

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