A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses

Understanding virus assembly could identify potential drug targets. Here the authors use a safe and efficient method to solve pathogenic flavivirus structures, revealing two lipid-like ligands within highly conserved pockets of the stem region of envelope protein that are important for virus maturat...

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Autores principales:	Joshua M. Hardy, Natalee D. Newton, Naphak Modhiran, Connor A. P. Scott, Hariprasad Venugopal, Laura J. Vet, Paul R. Young, Roy A. Hall, Jody Hobson-Peters, Fasséli Coulibaly, Daniel Watterson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e01baa3c70744276b2e3dffa7df9e256
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spelling	oai:doaj.org-article:e01baa3c70744276b2e3dffa7df9e2562021-12-02T18:24:58ZA unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses10.1038/s41467-021-22773-12041-1723https://doaj.org/article/e01baa3c70744276b2e3dffa7df9e2562021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22773-1https://doaj.org/toc/2041-1723Understanding virus assembly could identify potential drug targets. Here the authors use a safe and efficient method to solve pathogenic flavivirus structures, revealing two lipid-like ligands within highly conserved pockets of the stem region of envelope protein that are important for virus maturation.Joshua M. HardyNatalee D. NewtonNaphak ModhiranConnor A. P. ScottHariprasad VenugopalLaura J. VetPaul R. YoungRoy A. HallJody Hobson-PetersFasséli CoulibalyDaniel WattersonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua M. Hardy Natalee D. Newton Naphak Modhiran Connor A. P. Scott Hariprasad Venugopal Laura J. Vet Paul R. Young Roy A. Hall Jody Hobson-Peters Fasséli Coulibaly Daniel Watterson A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
description	Understanding virus assembly could identify potential drug targets. Here the authors use a safe and efficient method to solve pathogenic flavivirus structures, revealing two lipid-like ligands within highly conserved pockets of the stem region of envelope protein that are important for virus maturation.
format	article
author	Joshua M. Hardy Natalee D. Newton Naphak Modhiran Connor A. P. Scott Hariprasad Venugopal Laura J. Vet Paul R. Young Roy A. Hall Jody Hobson-Peters Fasséli Coulibaly Daniel Watterson
author_facet	Joshua M. Hardy Natalee D. Newton Naphak Modhiran Connor A. P. Scott Hariprasad Venugopal Laura J. Vet Paul R. Young Roy A. Hall Jody Hobson-Peters Fasséli Coulibaly Daniel Watterson
author_sort	Joshua M. Hardy
title	A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
title_short	A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
title_full	A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
title_fullStr	A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
title_full_unstemmed	A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
title_sort	unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e01baa3c70744276b2e3dffa7df9e256
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A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses

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