Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results

Ismail Ahmed Nagib Omar, Hosny Ahmed Zein Ophthalmology Department, Faculty of Medicine, Minia University, El-Minya, EgyptCorrespondence: Ismail Ahmed Nagib OmarOphthalmology Department, Faculty of Medicine, Minia University, P O Box 61519, El-Minya 61111, EgyptTel +201002554116Email ismail.omar@mu....

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Autores principales:	Omar IAN, Zein HA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	accelerated cross linking keratoconus aberrations. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e01cb62fa3284e939d36cb431b901ecb
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spelling	oai:doaj.org-article:e01cb62fa3284e939d36cb431b901ecb2021-12-02T05:42:28ZAccelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results1177-5483https://doaj.org/article/e01cb62fa3284e939d36cb431b901ecb2019-12-01T00:00:00Zhttps://www.dovepress.com/accelerated-epithelium-off-corneal-collagen-cross-linking-for-keratoco-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ismail Ahmed Nagib Omar, Hosny Ahmed Zein Ophthalmology Department, Faculty of Medicine, Minia University, El-Minya, EgyptCorrespondence: Ismail Ahmed Nagib OmarOphthalmology Department, Faculty of Medicine, Minia University, P O Box 61519, El-Minya 61111, EgyptTel +201002554116Email ismail.omar@mu.edu.egPurpose: The main aim of the study was to report visual, refractive, topographic, and aberrometric results of accelerated CXL in patients with keratoconus who were followed for 12 months and to highlight the important parameters that can be used in follow-up.Settings: It was a prospective interventional non-randomized case series study, in which 40 keratoconus eyes of 40 patients were studied in the period between April 2016 and July 2018.Methods: All eyes were examined preoperatively and post-accelerated CXL to evaluate visual acuity, refractive state, keratometric values, keratoconus indices, and corneal higher order aberrations (HOAs).Results: The mean age of the studied patients was 28.4 ± 8.6 years (18–37years). One year after cross-linking, 11.6% of the eyes gained two lines of the UCVA, 26.4% of the eyes gained one line, 49.8% showed no change, 7.1% lost one line, and 5.1% lost two lines. Postoperative  BCVA showed 13.7% of the eyes gained at least two lines, 32.5% gained one line, 49.9% had no change, and 3.9% lost one line. The keratometric values changed significantly after CXL; K1 decreased by a mean of 0.41D, K2 by 0.62D while Kmax by 1.57 D. The significant changes in keratoconus indices were in index of vertical asymmetry (IVA), index of surface variance (ISV), and keratoconus index (KI). Vertical coma, spherical aberrations, and trefoil decreased significantly at 12 months compared to baseline values (p = 0.04, 0.017, 0.025, respectively).Conclusion: Keratoconus indices especially ISV, IVA, and KI along with HOAsparticularly vertical coma, spherical aberrations, and trefoil can add value beside keratometric readings in the follow-up of eyes treated with accelerated CXL.Keywords: accelerated, cross-linking, keratoconus, aberrationsOmar IANZein HADove Medical Pressarticleacceleratedcross linkingkeratoconusaberrations.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2385-2394 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	accelerated cross linking keratoconus aberrations. Ophthalmology RE1-994
spellingShingle	accelerated cross linking keratoconus aberrations. Ophthalmology RE1-994 Omar IAN Zein HA Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results
description	Ismail Ahmed Nagib Omar, Hosny Ahmed Zein Ophthalmology Department, Faculty of Medicine, Minia University, El-Minya, EgyptCorrespondence: Ismail Ahmed Nagib OmarOphthalmology Department, Faculty of Medicine, Minia University, P O Box 61519, El-Minya 61111, EgyptTel +201002554116Email ismail.omar@mu.edu.egPurpose: The main aim of the study was to report visual, refractive, topographic, and aberrometric results of accelerated CXL in patients with keratoconus who were followed for 12 months and to highlight the important parameters that can be used in follow-up.Settings: It was a prospective interventional non-randomized case series study, in which 40 keratoconus eyes of 40 patients were studied in the period between April 2016 and July 2018.Methods: All eyes were examined preoperatively and post-accelerated CXL to evaluate visual acuity, refractive state, keratometric values, keratoconus indices, and corneal higher order aberrations (HOAs).Results: The mean age of the studied patients was 28.4 ± 8.6 years (18–37years). One year after cross-linking, 11.6% of the eyes gained two lines of the UCVA, 26.4% of the eyes gained one line, 49.8% showed no change, 7.1% lost one line, and 5.1% lost two lines. Postoperative  BCVA showed 13.7% of the eyes gained at least two lines, 32.5% gained one line, 49.9% had no change, and 3.9% lost one line. The keratometric values changed significantly after CXL; K1 decreased by a mean of 0.41D, K2 by 0.62D while Kmax by 1.57 D. The significant changes in keratoconus indices were in index of vertical asymmetry (IVA), index of surface variance (ISV), and keratoconus index (KI). Vertical coma, spherical aberrations, and trefoil decreased significantly at 12 months compared to baseline values (p = 0.04, 0.017, 0.025, respectively).Conclusion: Keratoconus indices especially ISV, IVA, and KI along with HOAsparticularly vertical coma, spherical aberrations, and trefoil can add value beside keratometric readings in the follow-up of eyes treated with accelerated CXL.Keywords: accelerated, cross-linking, keratoconus, aberrations
format	article
author	Omar IAN Zein HA
author_facet	Omar IAN Zein HA
author_sort	Omar IAN
title	Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results
title_short	Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results
title_full	Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results
title_fullStr	Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results
title_full_unstemmed	Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results
title_sort	accelerated epithelium-off corneal collagen cross-linking for keratoconus: 12-month results
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/e01cb62fa3284e939d36cb431b901ecb
work_keys_str_mv	AT omarian acceleratedepitheliumoffcornealcollagencrosslinkingforkeratoconus12monthresults AT zeinha acceleratedepitheliumoffcornealcollagencrosslinkingforkeratoconus12monthresults
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Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results

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