Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19
Viral and host immune kinetics during acute COVID-19 and after remission of acute symptoms need better characterization. SARS-CoV-2 RNA, anti-SARS-CoV-2 IgA, IgM, and IgG antibodies, and proinflammatory cytokines were measured in sequential samples from hospitalized COVID-19 patients during acute in...
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MDPI AG
2021
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oai:doaj.org-article:e020e2b920b840eca4d9f648365b86e02021-11-25T18:24:39ZElevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-1910.3390/microorganisms91122592076-2607https://doaj.org/article/e020e2b920b840eca4d9f648365b86e02021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2259https://doaj.org/toc/2076-2607Viral and host immune kinetics during acute COVID-19 and after remission of acute symptoms need better characterization. SARS-CoV-2 RNA, anti-SARS-CoV-2 IgA, IgM, and IgG antibodies, and proinflammatory cytokines were measured in sequential samples from hospitalized COVID-19 patients during acute infection and six months following diagnosis. Twenty four laboratory confirmed COVID-19 patients with mild/moderate and severe COVID-19 were included. Most were males (83%) with a median age of 61 years. Twenty one percent were admitted to the intensive care unit (ICU) and eight of them (33.3%) met the criteria for severe COVID-19 disease. A delay in SARS-CoV-2 levels’ decline during the first six days of follow up, and viral load persistence until month 3 were related to severe COVID-19, but not viral load levels at the diagnosis. Higher levels of anti-SARS-CoV-2 IgA, IgM, IgG and the cytokines IL-6, IL-8 and MIP-1β at the diagnosis time were related to the severe COVID-19 outcome. Higher levels of MIP-1β, IL-1β, MIP-1α and IFN-γ were observed at month 1 and 3 during mild/moderate disease, compared to severe COVID-19. IgG persisted at low levels after six months of diagnosis. In conclusion, higher concentrations of IgA, IgM, and IgG, and IL-6, IL-8 and MIP-1β are identified as early predictors of COVID-19 severity, whereas no significant association is found between baseline SARS-COV-2 viral load and COVID-19 severity.Helena CodinaIrene VieitezAlicia Gutierrez-ValenciaVasso SkouridouCristina MartínezLucía PatiñoMariluz Botero-GallegoMaría Trujillo-RodríguezAna Serna-GallegoEsperanza Muñoz-MuelaMaría M. BobilloAlexandre PérezJorge Julio Cabrera-AlvarManuel CrespoCiara K. O’SullivanEzequiel Ruiz-MateosEva PovedaMDPI AGarticleSARS-CoV-2severe COVID-19anti-SARS-CoV-2 antibodiescytokinesviral loadBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2259, p 2259 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
SARS-CoV-2 severe COVID-19 anti-SARS-CoV-2 antibodies cytokines viral load Biology (General) QH301-705.5 |
| spellingShingle |
SARS-CoV-2 severe COVID-19 anti-SARS-CoV-2 antibodies cytokines viral load Biology (General) QH301-705.5 Helena Codina Irene Vieitez Alicia Gutierrez-Valencia Vasso Skouridou Cristina Martínez Lucía Patiño Mariluz Botero-Gallego María Trujillo-Rodríguez Ana Serna-Gallego Esperanza Muñoz-Muela María M. Bobillo Alexandre Pérez Jorge Julio Cabrera-Alvar Manuel Crespo Ciara K. O’Sullivan Ezequiel Ruiz-Mateos Eva Poveda Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19 |
| description |
Viral and host immune kinetics during acute COVID-19 and after remission of acute symptoms need better characterization. SARS-CoV-2 RNA, anti-SARS-CoV-2 IgA, IgM, and IgG antibodies, and proinflammatory cytokines were measured in sequential samples from hospitalized COVID-19 patients during acute infection and six months following diagnosis. Twenty four laboratory confirmed COVID-19 patients with mild/moderate and severe COVID-19 were included. Most were males (83%) with a median age of 61 years. Twenty one percent were admitted to the intensive care unit (ICU) and eight of them (33.3%) met the criteria for severe COVID-19 disease. A delay in SARS-CoV-2 levels’ decline during the first six days of follow up, and viral load persistence until month 3 were related to severe COVID-19, but not viral load levels at the diagnosis. Higher levels of anti-SARS-CoV-2 IgA, IgM, IgG and the cytokines IL-6, IL-8 and MIP-1β at the diagnosis time were related to the severe COVID-19 outcome. Higher levels of MIP-1β, IL-1β, MIP-1α and IFN-γ were observed at month 1 and 3 during mild/moderate disease, compared to severe COVID-19. IgG persisted at low levels after six months of diagnosis. In conclusion, higher concentrations of IgA, IgM, and IgG, and IL-6, IL-8 and MIP-1β are identified as early predictors of COVID-19 severity, whereas no significant association is found between baseline SARS-COV-2 viral load and COVID-19 severity. |
| format |
article |
| author |
Helena Codina Irene Vieitez Alicia Gutierrez-Valencia Vasso Skouridou Cristina Martínez Lucía Patiño Mariluz Botero-Gallego María Trujillo-Rodríguez Ana Serna-Gallego Esperanza Muñoz-Muela María M. Bobillo Alexandre Pérez Jorge Julio Cabrera-Alvar Manuel Crespo Ciara K. O’Sullivan Ezequiel Ruiz-Mateos Eva Poveda |
| author_facet |
Helena Codina Irene Vieitez Alicia Gutierrez-Valencia Vasso Skouridou Cristina Martínez Lucía Patiño Mariluz Botero-Gallego María Trujillo-Rodríguez Ana Serna-Gallego Esperanza Muñoz-Muela María M. Bobillo Alexandre Pérez Jorge Julio Cabrera-Alvar Manuel Crespo Ciara K. O’Sullivan Ezequiel Ruiz-Mateos Eva Poveda |
| author_sort |
Helena Codina |
| title |
Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19 |
| title_short |
Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19 |
| title_full |
Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19 |
| title_fullStr |
Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19 |
| title_full_unstemmed |
Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19 |
| title_sort |
elevated anti-sars-cov-2 antibodies and il-6, il-8, mip-1β, early predictors of severe covid-19 |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/e020e2b920b840eca4d9f648365b86e0 |
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